Figure 1. Effect of constitutive Rap1 expression (cRap1) and/or 8CPT treatment on PC3 xenograft growth.

(A and B) Left Panel: Tumor volume (expressed in mm³) of human PC3 and PC3-cRap1 xenografts treated as indicated was measured as described in Methods. Day 0 represents the first day of treatment; *p<0.05, n = 7 for each group. Right Panel: Images of a representative tumor from each treatment group at the end of the experiment (Day 28). (C) Tumor volume (expressed in mm³) of human PC3 and PC3-cRap1 xenografts treated as indicated was measured as in A; *p<0.05, n = 7 for each group. (D) Tumors from panel C were weighed at the end of the experiment (Day 28) and expressed in grams; *p<0.05; (n = 7).