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. 2012 Nov 15;7(11):e48832. doi: 10.1371/journal.pone.0048832

Figure 1. Reactivation of latent HIV-1 in latently infected cells by M344 and TSA.

Figure 1

(A) The structure of M344 and TSA. (B) J-Lat clones A7 cells, which have an integrated GFP/Tat construct under control of the HIV-1 LTR, were treated with M344 or TSA at the indicated concentrations for 72 hours. The percentage of cells expressing GFP was measured by flow cytometry, to determine the level of HIV-1 expression. Results are presented as fluorescence histograms. (C) Dose-dependent effects of M344 on HIV-1 production. Data represent the means±standard deviations of three independent experiments.