Table I.

Broad biological functions of breast cancer protein profiles.

	Protein profiles a			Upregulated proteins			Downregulated proteins
Biological functions	Observed nos.	Expected nos.	P-value	Observed nos.	Expected nos.	P-value	Observed nos.	Expected nos.	P-value
Antioxidant activity	4	0.75	7.10e−3	10	1.41	2.31e−6	3	0.43	9.28e−3
Apoptosis	36	24.84	1.81e−2	73	46.96	1.78e−4	24	14.17	8.92e−3
Binding	158	173.60	7.86e−2	358	328.21	2.39e−2	126	99.01	6.36e−4
Calmodulin	7	1.60	1.34e−3	1	0.85	5.72e−1	1	0.48	3.84e−1
Catalytic activity	213	137.21	3.29e−13	375	259.42	4.35e−16	104	78.25	5.80e−4
Cell adhesion	13	4.52	8.11e−4	12	2.39	7.51e−6	0	1.36	2.55e−1
Cell-cell signaling	19	34.23	2.61e−3	43	64.71	2.04e−3	15	19.52	1.74e−1
Chaperone	28	6.32	1.56e−10	22	3.34	8.96e−12	5	1.91	4.40e−2
Cytoskeletal protein	55	21.44	5.64e−10	27	11.34	4.24e−5	16	6.47	9.47e−4
Defense/immunity protein	10	5.20	3.93e−2	2	2.75	4.81e−1	8	1.57	2.15e−4
Extracellular matrix protein	7	3.50	6.50e−2	1	1.85	4.47e−1	5	1.06	4.50e−3
G-protein coupled receptor	1	21.73	6.62e−9	0	11.49	8.94e−6	0	6.56	1.32e−3
Hsp70 family chaperone	5	0.63	4.94e−4	4	0.33	3.95e−4	1	0.19	1.74e−1
Isomerase activity	12	4.86	4.19e−3	26	9.19	3.65e−6	6	2.77	6.18e−2
Lyase activity	17	5.30	3.54e−5	24	10.01	1.11e−4	6	3.02	8.50e−2
Metabolic process	283	212.58	2.58e−10	529	401.91	1.39e−16	157	121.24	1.64e−5
Metalloprotease	16	7.05	2.47e−3	7	3.73	8.36e−2	4	2.13	1.66e−1
Oxidoreductase activity	59	18.08	3.86e−15	105	34.18	1.40e−23	31	10.31	7.17e−8
Peptidase activity	28	18.44	2.06e−2	53	34.86	2.10e−3	14	10.51	1.72e−1
Peptidase inhibitor activity	11	4.55	6.96e−3	22	8.61	8.61e−5	6	2.60	4.79e−2
Peroxidase activity	4	0.69	5.55e−3	8	1.31	6.73e−5	2	0.40	6.04e−2
Protease	42	23.14	2.23e−4	22	12.24	6.84e−3	11	6.98	9.46e−2
Protease inhibitor	15	5.30	3.93e−4	6	2.80	6.48e−2	5	1.60	2.32e−2
Protein transport	67	42.33	1.43e−4	111	80.02	3.43e−4	23	24.14	4.58e−1
Receptor activity	30	46.49	4.84e−3	56	87.90	9.95e−5	19	26.51	7.17e−2
Structural molecule activity	62	38.26	1.39e−4	133	72.34	1.34e−11	48	21.82	2.42e−7
Transcription factor	44	100.49	3.02e−11	20	53.15	5.28e−8	17	30.31	4.39e−3
Transfer/carrier protein	29	12.06	2.12e−5	10	6.38	1.11e−1	7	3.64	7.51e−2
Transferase activity	59	40.96	3.27e−3	96	77.45	1.85e−2	25	23.36	3.92e−1
Translation factor	10	2.72	5.21e−4	6	1.44	3.61e−3	3	0.82	5.03e−2
Transport	99	73.47	1.18e−3	183	138.90	5.80e−5	50	41.90	1.04e−1
Vesicle coat protein	6	1.46	3.86e−3	6	0.77	1.48e−4	0	0.44	6.44e−1
Unclassified	93	171.80	6.09e−15	95	173.91	7.31e−15	45	97.98	2.04e−12

^aProtein profiles included all the breast cancer proteins.