. 2012 Nov 15;7(11):e49308. doi: 10.1371/journal.pone.0049308

Table 2. Stratification analysis for associations between ERCC1 variant genotypes and gastric cancer risk in an Eastern Chinese population.

Variables	rs2298881 (cases/controls)		Adjusted OR^a (95% CI)	P ^a	P ^het	rs3212986 (cases/controls)		Adjusted OR^a (95% CI)	P ^a	P ^het	rs11615 (cases/controls)		Adjusted OR^a (95% CI)	P ^a	P^het	Combined effect of risk genotypes (cases/controls)		Adjusted OR^a (95% CI)	P ^a	P ^het
	AA	AC/CC				CC	AC/AA				GG	AG/AA				0–1	2–3
Median age, yr
≤59	79/107	499/503	1.35 (0.98–1.85)	0.064	0.910	277/288	301/322	0.98 (0.78–1.23)	0.850	0.335	308/369	270/241	1.34 (1.07–1.69)	0.013	0.248	96/144	482/466	1.55 (1.16–2.07)	0.003	0.931
>59	72/97	475/489	1.35 (0.97–1.89)	0.080		249/286	298/300	1.13 (0.89–1.44)	0.306		302/338	245/248	1.14 (0.90–1.45)	0.283		85/132	462/454	1.62 (1.19–2.20)	0.002
Sex
Male	115/141	685/685	1.23 (0.94–1.61)	0.135	0.261	385/406	415/420	1.03 (0.85–1.25)	0.783	0.823	439/484	361/342	1.18 (0.97–1.44)	0.102	0.382	136/192	664/634	1.48 (1.16–1.89)	0.002	0.374
Female	36/63	289/307	1.64 (1.05–2.56)	0.029		141/168	184/202	1.05 (0.77–1.42)	0.767		171/223	154/147	1.38 (1.02–1.88)	0.036		45/84	280/286	1.82 (1.22–2.72)	0.003
Smoking status
Never	92/99	594/511	1.27 (0.93–1.74)	0.128	0.704	307/281	379/329	1.08 (0.87–1.35)	0.502	0.688	386/365	300/245	1.15 (0.92–1.44)	0.210	0.622	110/135	576/475	1.50 (1.13–1.99)	0.005	0.405
Former	3/18	14/102	0.73 (0.18–2.89)	0.652		9/52	8/68	0.62 (0.21–1.80)	0.378		8/68	9/52	1.60 (0.55–4.63)	0.388		4/24	13/96	0.72 (0.21–2.48)	0.606
Current	56/87	366/379	1.49 (1.03–2.14)	0.035		210/241	212/225	1.05 (0.81–1.36)	0.745		216/274	206/192	1.38 (1.06–1.80)	0.018		67/117	355/349	1.76 (1.26–2.47)	0.001
Drinking status
Never	114/142	741/709	1.31 (1.00–1.71)	0.0497	0.826	383/404	472/447	1.12 (0.92–1.35)	0.260	0.178	475/492	380/359	1.10 (0.91–1.33)	0.337	0.032	138/191	717/660	1.51 (1.18–1.93)	0.001	0.569
Ever	37/62	233/283	1.41 (0.90–2.19)	0.135		143/170	127/175	0.87 (0.63–1.20)	0.404		135/215	135/130	1.67 (1.20–2.31)	0.002		43/85	227/260	1.75 (1.16–2.64)	0.007
Tumor site
GCA	42/204	263/992	1.31 (0.91–1.88)	0.150	0.855	158/574	147/622	0.87 (0.67–1.12)	0.268	0.078	164/707	141/489	1.24 (0.96–1.60)	0.106	0.875	52/276	253/920	1.48 (1.07–2.07)	0.020	0.638
NGCA	109/204	711/992	1.33 (1.03–1.71)	0.027		368/574	452/622	1.11 (0.93–1.33)	0.250		446/707	374/489	1.23 (1.03–1.47)	0.026		129/276	691/920	1.59 (1.26–2.01)	<0.0001
Clinical stage
I+II	54/204	422/992	1.58 (1.15–2.18)	0.005	0.134	221/574	255/622	1.05 (0.85–1.30)	0.652	0.876	248/707	228/489	1.33 (1.08–1.65)	0.009	0.313	68/276	408/920	1.78 (1.33–2.38)	0.0001	0.223
III+IV	97/204	552/992	1.17 (0.90–1.53)	0.237		305/574	344/622	1.03 (0.85–1.25)	0.771		362/707	287/489	1.15 (0.95–1.40)	0.158		113/276	536/920	1.42 (1.11–1.81)	0.005

GCA, gastric cardia adenocarcinoma; NGCA, non-gastric cardia adenocarcinoma.

The results were in bold, if the 95% CI excluded 1 or P<0.05.

Obtained in logistic regression models with adjustment for age, sex, smoking and drinking status.