Skip to main content
. 2012 Aug 30;4(5):1047–1055. doi: 10.3892/ol.2012.887

Table V.

Histological subtypes of DFSP as described by Kim (29).

Subtype Histological characteristics Clinical features
‘Classic’ DFSP Monomorphous fusiform cells (spindle cells) with large elongated nucleus and poor cytoplasm, low mitotic index Most common subtype (90%)
Rare metastasis (≤0.5%)
Giant cell fibroblastoma Giant multinucleated cells, sinusoidal vessels, myxoid stroma Frequently observed in childhood
Bednar tumor Melanocytes and deposits of melanin Observed in African and American patients
Sclerotic DFSP Abundant stroma with several layers of collagen and areas of denser cellularity Rare subtype
Myxoid DFSP Spindle cells grouped in nodules with eosinophilic cytoplasm Rare subtype
Atrophic DFSP Atrophic mid-dermis with subcutaneous tissue close to the epidermis Frequently observed in childhood
Fibrosarcomatous DFSP High mitotic index with high cellularity and marked nuclear pleomorphism Subtype with the highest recurrence rate and metastatic potential, most aggressive variant

DFSP, dermatofibrosarcoma protuberans.