Table V.
Subtype | Histological characteristics | Clinical features |
---|---|---|
‘Classic’ DFSP | Monomorphous fusiform cells (spindle cells) with large elongated nucleus and poor cytoplasm, low mitotic index | Most common subtype (90%) Rare metastasis (≤0.5%) |
Giant cell fibroblastoma | Giant multinucleated cells, sinusoidal vessels, myxoid stroma | Frequently observed in childhood |
Bednar tumor | Melanocytes and deposits of melanin | Observed in African and American patients |
Sclerotic DFSP | Abundant stroma with several layers of collagen and areas of denser cellularity | Rare subtype |
Myxoid DFSP | Spindle cells grouped in nodules with eosinophilic cytoplasm | Rare subtype |
Atrophic DFSP | Atrophic mid-dermis with subcutaneous tissue close to the epidermis | Frequently observed in childhood |
Fibrosarcomatous DFSP | High mitotic index with high cellularity and marked nuclear pleomorphism | Subtype with the highest recurrence rate and metastatic potential, most aggressive variant |
DFSP, dermatofibrosarcoma protuberans.