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. Author manuscript; available in PMC: 2013 Jun 14.
Published in final edited form as: J Med Chem. 2012 May 24;55(11):4968–4977. doi: 10.1021/jm201442t

Figure 4.

Figure 4

Biochemical characterization of 5 selected compounds. (A) EMSA-based analyses of the binding of compounds 1, 5, 8, 9, or 10 to NC’ showing the displacement of FSL-2 from the NC’- FSL-2 complex or the internal control utilizing 10 µM unlabeled SL-2 DNA. (B) Resonant waveguide grating-based analyses of the binding of compounds 1, 5, 8, 9, or 10 to immobilized NC’. Real-time kinetics of compound binding was monitored by peak wavelength value shifts over time.