Table 4.
Association of oral squamous cell carcinoma with self-reported history of allergies stratified by site and HPV status, Seattle metropolitan area, 1985–1989 and 1990–1995.a
| Allergy and HPV status | Oral cavity | Oropharynx | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases exposed | Controls exposed | OR | 95% CI | Cases exposed | Controls exposed | OR | 95% CI | |||||
| N | %b | n | %b | n | %b | n | %b | |||||
| Any allergies | ||||||||||||
| HPV-16 Serology | ||||||||||||
| positive | 44 | 39.6 | 98 | 50.3 | 0.78 | (0.46–1.32) | 35 | 44.3 | 98 | 50.3 | 0.85 | (0.48–1.51) |
| negative | 50 | 43.1 | 191 | 52.0 | 0.69 | (0.43–1.10) | 24 | 44.4 | 191 | 52.0 | 0.68 | (0.36–1.29) |
| HPV DNAc | ||||||||||||
| positive | 6 | 54.6 | 306 | 49.9 | 0.99 | (0.28–3.45) | 17 | 56.7 | 306 | 49.9 | 1.27 | (0.59–2.72) |
| negative | 58 | 41.7 | 306 | 49.9 | 0.78 | (0.52–1.18) | 23 | 50.0 | 306 | 49.9 | 0.84 | (0.43–1.63) |
| Airborne allergiesd | ||||||||||||
| HPV-16 Serology | ||||||||||||
| positive | 20 | 18.0 | 64 | 32.8 | 0.58 | (0.31–1.10) | 18 | 22.8 | 64 | 32.8 | 0.70 | (0.36–1.35) |
| negative | 30 | 25.9 | 127 | 34.6 | 0.77 | (0.46–1.29) | 10 | 18.5 | 127 | 34.6 | 0.43 | (0.19–0.95) |
| HPV DNAc | ||||||||||||
| positive | 5 | 45.5 | 202 | 33.0 | 1.93 | (0.54–6.93) | 10 | 33.3 | 202 | 33.0 | 0.85 | (0.38–1.92) |
| negative | 29 | 20.9 | 202 | 33.0 | 0.65 | (0.40–1.06) | 10 | 21.7 | 202 | 33.0 | 0.54 | (0.24–1.21) |
a
Adjusted for age, sex, race, education, pack years of smoking, smoking status (ever/never), and average alcoholic drinks per week.
b
Percentages reflect the proportion of the whole in each category made up by the “n” to the left of each”%.” Unexposed percentages are the complement of percentages shown.
c
HPV types 16, 18, 31, 33, or 35. No HPV DNA data were available for controls.
d
Includes allergies to pollens, dust and mold.