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. 2012 Aug 8;37(13):2797–2808. doi: 10.1038/npp.2012.150

Figure 4.

Figure 4

FKBP51 mRNA expression correlates with behavioral and neuroendocrine parameters in stressed animals. (a, b) The stronger the FKBP51 expression levels in the dorsal hippocampus, the lower the time spent with active stress coping in the forced swim test (r=−0.948, p<0.001). This effect is only visible in a system activated by CSDS, as there is no significant correlation after the recovery period. (c, d) Although CSDS reduced locomotion in the open field, an enhanced FKBP51 expression counteracts this behavioral phenotype (r=0.715, p<0.05), which is also exclusively visible in an activated system. (e–h) Circulating corticosterone is directly correlated to the increased FKBP51 levels at both the response to an acute stressor and the recovery from it (response: r=−0.771, p<0.01; recovery: r=−0.742, p<0.05). *Significant correlation, p<0.05; other abbreviations as in Figures 1 and 2.