Figure 5.

GR sensitivity is increased depending on FKBP51 levels. (a) Metallothionein-1 (MT-1) mRNA levels correlate significantly with FKBP51 levels in the CA1 region of the hippocampus, when animals underwent the CSDS paradigm (r=0.827, p<0.01). As MT-1 is a downstream target of glucocorticoid receptors (GRs), this suggests increased GR sensitivity in response to FKBP51 activation. (b) MT-1 mRNA also correlates to struggling behavior in the FST (r=−0.782, p<0.01). (c) Animals that underwent the CSDS paradigm have an increased rate of GR translocation to the nucleus compared with control mice (T₁₄=−3.113, p<0.01). (d) Protein bands of GR (94 kD) and actin (42 kD) in the cytosolic and nucleic fraction of hippocampal tissue. ^*Significant from control, p<0.05; other abbreviations as in Figures 1 and 2.