Table 3. Estimated area under the ROC curve for input parameters from published empirical studies.

						Estimated AUC
						Simulation		Analytical
									Moonesinghe		Gail
Genetic effects	First authorRef	Disease outcome	Population disease risk (%)Ref	Number of genetic variants	Published AUC	Pepe per allele	Janssens All	Lu per genotype	Dominant	Recessive	per allele
Per genotype	Van Hoek14	Type 2 diabetes	2014	18	0.60	0.59	0.59	—a	0.56	0.57	—a
Per allele	Mealiffe15	Breast cancer	12.1516	7	0.59	0.59	0.59	0.59	0.57	0.56	0.59
	Helfand17	Prostate cancer	16.2216	9	0.66	0.68	0.68	0.68	0.63	0.62	0.68
	Hu18	Type 2 diabetes	2014	11	0.62	0.63	0.63	0.63	0.58	0.59	0.63
	Lin19	Type 2 diabetes	2014	15	0.59	0.61	0.61	—a	0.58	0.57	—a
	Takahashi20	Osteoarthritis (knee)	27.81,2	3	0.55	0.56	0.56	0.56	0.53	0.53	0.56
	Qi22	Type 2 diabetes	2014	17	0.62	0.64	0.64	—a	0.60	0.58	—a
Combination of per genotype and dominant/ recessive	Seddon23	Age-related macular degeneration	6.524	14	0.82	—b	0.81	0.80	0.77	0.72	—b

Abbreviations: AUC, area under receiver operating characteristic curve; ROC, receiver operating characteristic.

^aAUC cannot be obtained because of insufficient computer memory.

^bPer allele odds ratios and frequencies cannot be reconstructed from the dominant/recessive data.