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. 2012 Nov 16;6:85. doi: 10.3389/fncir.2012.00085

Figure 1.

Figure 1

Impaired MF-CA3 transmission but normal MF excitability in activated DG-TeTX mice. (A) Representative fEPSP waveforms recorded in CA3 stratum lucidum evoked by stimulation in the DG GC layer obtained in control and activated DG-TeTX (DG-TeTX) mice in control (ACSF, upper traces) and DCGIV (1 μM) containing ACSF (DCGIV, middle traces). Traces are the average of 6 consecutive individual sweeps obtained in each condition (scale bars 20 ms/0.5 mV). The pure MF-CA3-mediated fEPSP is obtained by digital subtraction of the DCGIV condition waveform from the control condition waveform (bottom traces). (B) Group data bar chart summary of the MF-CA3 fEPSP areas and AFV amplitudes observed in control (n = 10 slices from 7 animals) and DG-TeTX (n = 7 slices from 5 animals) mice. (C) Representative fEPSP waveforms from control and DG-TeTX mice obtained at the three different stimulus intensities indicated (traces are the average of 6 events obtained at each stimulus intensity, scale bars 5 ms/0.5 mV). (D) AFV input-output functions for control (n = 8 slices from 5 mice) and activated DG-TeTX mice (n = 10 slices, from 5 mice).