Table 1.
Summary of electrophysiological properties of mature granule cells.
| Control mice | DG-TeTX mice | |
|---|---|---|
| Intrinsic membrane properties | (n = 14 cells from 5 mice) | (n = 15 cells from 4 mice) |
| Resting potential (mV) | −71 ± 1 | −68 ± 2 |
| Input resistance (MΩ) | 199 ± 14 | 225 ± 27 |
| Time constant (ms) | 23 ± 2 | 19 ± 2 |
| Membrane capacitance (pF) | 117 ± 9 | 94 ± 8 |
| Frequency at 2× threshold (Hz) | 23 ± 2 | 19 ± 2 |
| Spike threshold (mV) | −35 ± 2 | −35 ± 2 |
| Spike amplitude (mV) | 77 ± 3 | 74 ± 3 |
| Spike half-width (ms) | 0.84 ± 0.04 | 0.87 ± 0.06 |
| Spike maximal decay (mV/ms) | −93 ± 5 | −90 ± 6 |
| IPSC properties | (n = 8 cells from 3 mice) | (n = 3 cells from 2 mice) |
| sIPSC amplitude (pA) | −60 ± 5 | −64 ± 14 |
| sIPSC frequency (Hz) | 5 ± 0.4 | 4.3 ± 1.1 |
| sIPSC τdecay (ms) | 7.6 ± 0.4 | 8.2 ± 0.5 |
| GABAtonic (pA) | −30 ± 8 | −45 ± 19 |
| EPSC properties | (n = 6 cells s/eEPSCs, 5 cells LTP from 3 mice) | (n = 6 cells s/eEPSCs, 6 cells LTP from 4 mice) |
| sEPSC amplitude (pA) | −11 ± 1 | −10 ± 0.6 |
| sEPSC frequency (Hz) | 1.6 ± 0.3 | 1.3 ± 0.2 |
| sEPSC τdecay (ms) | 5.6 ± 0.5 | 5.8 ± 0.3 |
| eEPSC AMPA/NMDA ratio | 1.3 ± 0.2 | 1.5 ± 0.2 |
| eEPSC PPR | 1.0 ± 0.04 | 1.2 ± 0.09 |
| eEPSCNMDA τdecay (ms) | 73 ± 3 | 83 ± 7 |
| eEPSC TBS LTP (% control) | 212 ± 47 | 191 ± 50 |