Table 6.
Acquired tetracycline resistance genes*.
| Mechanism | Gene | Length (nt) | Accession number | Coding region | Genera |
|---|---|---|---|---|---|
| Efflux | otr(B) | 1692 | AF079900 | 40… 1731 | Mycobacterium, Streptomyces |
| otr(C) | 1056 | AY509111 | 324… 1379 | Streptomyces | |
| tcr | 1539 | D38215 | 516… 2054 | Streptomyces | |
| tet(A) | 1200 | X00006 | 1328… 2527 | Acinetobacter, Aeromonas, Alcaligenes, Bordetella, Chryseobacterium, Citrobacter, Edwardsiella, Enterobacter, Escherichia, Flavobacterium, Klebsiella, Laribacter, Plesiomonas, Proteus, Pseudomonas, Salmonella, Serratia, Shigella, Variovorax, Veillonella, Vibrio | |
| tetA(P) | 1263 | L20800 | 1063… 2325 | Clostridium | |
| tet(B) | 1206 | J01830 | 1608… 2813 | Acinetobacter, Actinobacillus, Aeromonas, Aggregatibacter, Brevundimonas, Citrobacter, Enterobacter, Erwinia, Escherichia, Haemophilus, Klebsiella, Mannheimia, Moraxella, Neisseria, Pantoea, Pasteurella, Photobacterium, Plesiomonas, Proteus, Providencia, Pseudomonas, Roseobacter, Salmonella, Serratia, Shigella, Treponema, Vibrio, Yersinia | |
| tet(C) | 1191 | X01654 | 86… 1276 | Aeromonas, Bordetella, Chlamydia, Citrobacter, Enterobacter, Escherichia, Francisella, Halomonas, Klebsiella, Proteus, Pseudomonas, Roseobacter, Salmonella, Serratia, Shigella, Vibrio | |
| tet(D) | 1185 | X65876 | 1521… 2705 | Aeromonas, Alteromoas, Citrobacter, Edwardsiella, Enterobacter, Escherichia, Halomonas, Klebsiella, Morganella, Pasteurella, Photobacterium, Proteus, Salmonella, Shewanella, Shigella, Vibrio, Yersinia | |
| tet(E) | 1218 | L06940 | 21… 1238 | Aeromonas, Alcaligenes, Escherichia, Flavobacterium, Plesiomonas, Proteus, Providencia, Pseudomonas, Roseobacter, Serratia, Vibrio | |
| tet(G) | 1128 | AF071555 | 6644… 7771 | Acinetobacter, Brevundimonsa, Escherichia, Fusobacterium, Mannheimia, Ochrobactrum, Pasteurella, Proteus, Providencia, Pseudomonas, Roseobacter, Salmonella, Shewanella, Vibrio | |
| tet(H) | 1203 | U00792 | 716… 1918 | Acinetobacter, Actinobacillus, Histophilus, Mannheimia, Moraxella, Pasteurella, Psychrobacter | |
| tet(J) | 1197 | AF038993 | 1084… 2280 | Escherichia, Morganella, Proteus | |
| tet(K) | 1380 | M16217 | 305… 1684 | Bacillus, Clostridium, Enterococcus, Eubacterium, Haemophilus, Lactobacillus, Listeria, Mycobacterium, Nocardia, Peptostreptococcus, Staphylococcus, Streptococcus, Streptomyces | |
| tet(L) | 1377 | D00006 | 189… 1565 | Acinetobacter, Actinobacillus, Actinomyces, Bacillus, Bifidobacterium, Citrobacter, Clostridium, Enterobacter, Enterococcus, Escherichia, Flavobacterium, Fusobacterium, Geobacillus, Kurthia, Lactobacillus, Listeria, Mannheimia, Morganella, Mycobacterium, Nocardia, Ochrobactrum, Oceanobacillus, Paenibacillus, Pasteurella, Pediococcus, Peptostreptococcus, Proteus, Pseudomonas, Rahnella, Salmonella, Sporosarcina, Staphylococcus, Streptococcus, Streptomyces, Variovorax, Veillonella, Virgibacillus | |
| tet(V) | 1260 | AF030344 | 462… 1721 | Mycobacterium | |
| tet(Y) | 1176 | AF070999 | 1680… 2855 | Aeromonas, Escherichia, Photobacterium | |
| tet(Z) | 1155 | AF121000 | 11880… 13034 | Corynebacterium, Lactobacillus | |
| tet(30) | 1185 | AF090987 | 1130… 2314 | Agrobacterium | |
| tet(31) | 1233 | AJ250203 | 1651… 2883 | Aeromonas, Gallibacterium | |
| tet(33) | 1224 | AJ420072 | 22940… 24163 | Arthrobacter, Corynebacterium | |
| tet(35) | 1110 | AF353562 | 2213… 3322 | Stenotrophomonas, Vibrio | |
| tet(38) | 1353 | AY825285 | 1… 1353 | Staphylococcus | |
| tet(39) | 1188 | AY743590 | 749… 1936 | Acinetobacter, Alcaligenes, Brevundimonas, Enterobacter, Providencia, Stenotrophomonas | |
| tet(40) | 1221 | AM419751 | 14211… 15431 | Clostridium | |
| tet(41) | 1182 | AY264780 | 1825… 3006 | Serratia | |
| tet(42) | 1287 | EU523697 | 687… 1973 | Bacillus, Microbacterium, Micrococcus, Paenibacillus, Pseudomonas, Staphylococcus | |
| tet(43) | 1560 | GQ244501 | 60… 1619 | Uncultured | |
| Enzymatic | tet(X) | 1167 | M37699 | 586… 1752 | Bacteroides, Pseudomonas, Sphingobacterium |
| tet(34) | 465 | AB061440 | 306… 770 | Aeromonas, Pseudomonas, Serratia | |
| tet(37) | 327 | AF540889 | 1… 327 | Uncultured | |
| Ribosomal protection | otr(A) | 1992 | X53401 | 349… 2340 | Bacillus, Mycobacterium, Streptomyces |
| tetB(P) | 1959 | L20800 | 2309… 4267 | Clostridium | |
| tet(M) | 1920 | U08812 | 1981… 3900 | Abiotrophia, Acinetobacter, Actinomyces, Aerococcus, Aeromonas, Afipia, Arthrobacter, Bacillus, Bacterionema, Bacteroides, Bifidobacterium, Brachybacterium, Catenibacterium, Clostridium, Corynebacterium, Edwardsiella, Eikenella, Enterobacter, Enterococcus, Erysipelothrix, Escherichia, Eubacterium, Flavobacterium, Fusobacterium, Gardnerella, Gemella, Granulicatella, Haemophilus, Kingella, Klebsiella, Kurthia, Lactobacillus, Lactococcus, Listeria, Microbacterium, Mycoplasma, Neisseria, Paenibacillus, Pantoea, Pasteurella, Peptostreptococcus, Photobacterium, Prevotella, Pseudoalteromonas, Pseudomonas, Ralstonia, Selenomonas, Serratia, Shewanella, Staphylococcus, Streptococcus, Streptomyces, Ureaplasma, Veillonella, Vibrio | |
| tet(O) | 1920 | M18896 | 207… 2126 | Actinobacillus, Aerococcus, Anaerovibrio, Bifidobacterium, Butyrivibrio, Campylobacter, Clostridium, Enterococcus, Eubacterium, Fusobacterium, Gemella, Lactobacillus, Megasphaera, Mobiluncus, Neisseria, Peptostreptococcus, Psychrobacter, Staphylococcus, Streptococcus | |
| tet(Q) | 1926 | Z21523 | 362… 2287 | Anaerovibrio, Bacteroides, Capnocytophaga, Clostridium, Eubacterium, Fusobacterium, Gardnerella, Lactobacillus, Mitsuokella, Mobiluncus, Neisseria, Peptostreptococcus, Porphyromonas, Prevotella, Ruminococcus, Selenomonas, Streptococcus, Subdolgranulum, Veillonella | |
| tet(S) | 1926 | L09756 | 447… 2372 | Enterococcus, Lactobacillus, Lactococcus, Listeria, Staphylococcus, Streptococcus, Veillonella | |
| tet(T) | 1956 | L42544 | 478… 2433 | Lactobacillus, Streptococcus | |
| tet(W) | 1920 | AJ222769 | 3687… 5606 | Acidaminococcus, Actinomyces, Arcanobacterium, Bacillus, Bacteroides, Bifidobacterium, Butyrivibrio, Clostridium, Fusobacterium, Lactobacillus, Megasphaera, Mitsuokella, Neisseria, Porphyromonas, Prevotella, Roseburia, Selenomonas, Staphylococcus, Streptococcus, Streptomyces, Subdolgranulum, Veillonella | |
| tet(32) | 1920 | DQ647324 | 181… 2100 | Eubacterium, Streptococcus | |
| tet(36) | 1923 | AJ514254 | 2534… 4456 | Bacteroides, Clostridium, Lactobacillus | |
| tet(44) | 1923 | FN594949 | 25245… 27167 | Campylobacter, Clostricium | |
| tet | 1920 | M74049 | 343… 2261 | Streptomyces | |
| Unknown | tet(U) | 318 | U01917 | 413… 730 | Enterococcus, Staphylococcus, Streptococcus |
*
Last update: January 6th 2012. Adapted from http://faculty.washington.edu/marilynr/. The efflux genes tet(45) and tet(46) have been named but not yet published.