Table 7.
Acquired trimethoprim resistance genes*.
| Gene | Sub-family | Gene(s) included | Length (nt) | Accession number | Coding region | Genera |
|---|---|---|---|---|---|---|
| dfrA1 | dfrA1-group | dhfrIb, dfr1, dhfrI | 474 | X00926 | 236… 709 | Actinobacter, Enterobacter, Escherichia, Klebsiella, Laribacter, Morganella, Pasteurella, Proteus, Pseudomonas, Salmonella, Serratia, Shigella, Vibrio |
| dfrA3 | − | − | 489 | J03306 | 103… 591 | Salmonella |
| dfrA5 | dfrA1-group | dhfrV, dfrV | 474 | X12868 | 1306… 1779 | Actinobacter, Aeromonas, Comomonas, Enterobacter, Escherichia, Klebsiella, Pseudomonas, Salmonella, Vibrio |
| dfrA6 | dfrA1-group | dfrVI | 474 | Z86002 | 336… 809 | Proteus |
| dfrA7 | dfrA1-group | dhfrVII, dfrVII, dfrA17 | 474 | X58425 | 594… 1067 | Actinobacter, Escherichia, Proteus, Salmonella, Shigella |
| dfrA8 | − | − | 510 | U10186 | 711… 1220 | Escherichia |
| dfrA9 | − | − | 534 | X57730 | 726… 1259 | Escherichia |
| dfrA10 | − | − | 564 | L06418 | 5494… 6057 | Actinobacter, Escherichia, Klebsiella, Salmonella |
| dfrA12 | dfrA12-group | dhfrXII, dfr12 | 498 | Z21672 | 310… 807 | Actinobacter, Aeromonas, Citrobacter, Edwardsiella, Enterobacter, Escherichia, Klebsiella, Proteus, Providencia, Pseudomonas, Serratia, Salmonella, Staphylococcus, Stenotrophomonas |
| dfrA13 | dfrA12-group | − | 498 | Z50802 | 718… 1215 | Escherichia |
| dfrA14 | dfrA1-group | dhfrIb | 474 | Z50805 | 72… 545 | Achromobacter, Aeromonas, Escherichia, Klebsiella, Salmonella, Vibrio |
| dfrA15 | dfrA1-group | dhfrXVb | 474 | Z83311 | 357… 830 | Actinobacter, Enterobacter, Escherichia, Klebsiella, Morganella, Proteus, Pseudomonas, Vibrio |
| dfrA16 | dfrA1-group | dhfrXVI, dfr16 | 474 | AF174129 | 1352… 1825 | Aeromonas, Escherichia, Klebsiella, Salmonella |
| dfrA17 | dfrA1-group | dhfrXVII, dfr17 | 474 | AB126604 | 98… 571 | Actinobacter, Enterobacter, Escherichia, Klebsiella, Kluyvera, Laribacter, Pseudomonas, Salmonella, Serratia, Shigella, Staphylococcus, Stenotrophomonas |
| dfrA18 | − | dfrA19 | 570 | AJ310778 | 7004… 7573 | Enterobacter, Klebsiella, Salmonella |
| dfrA20 | − | − | 510 | AJ605332 | 1304… 1813 | Pasteurella |
| dfrA21 | dfrA12-group | dfrxiii | 498 | AY552589 | 1… 498 | Escherichia, Klebsiella, Salmonella |
| dfrA22 | dfrA12-group | dfr22, dfr23 | 498 | AJ628423 | 325… 822 | Escherichia, Klebsiella, Serratia |
| dfrA23 | − | − | 561 | AJ746361 | 6743… 7303 | Salmonella |
| dfrA24 | − | − | 558 | AJ972619 | 83… 640 | Escherichia |
| dfrA25 | dfrA1-group | − | 459 | DQ267940 | 54… 512 | Citrobacter, Klebsiella, Salmonella, Serratia |
| dfrA26 | − | – | 552 | AM403715 | 303… 854 | Escherichia |
| dfrA27 | dfrA1-group | dfr | 474 | EU675686 | 2543… 3016 | Aeromonas, Escherichia, Klebsiella, Serratia, Vibrio |
| dfrA28 | dfrA1-group | − | 474 | FM877476 | 116… 589 | Aeromonas |
| dfrA29 | − | dfrVII, dfrA7 | 472 | AM237806 | 615… 1086 | Salmonella |
| dfrA30 | − | dhfrV | 474 | AM997279 | 705… 1178 | Klebsiella |
| dfrA31 | − | dfr6 | 474 | AB200915 | 1832… 2305 | Escherichia, Vibrio |
| dfrA32 | dfrA1-group | − | 474 | GU067642 | 535… 1008 | Laribacter, Salmonella |
| dfrA33 | dfrA12-group | − | 498 | FM957884 | 88… 585 | Unknown |
| dfrB1 | − | dhfrIIa, dfr2a | 237 | U36276 | 717… 953 | Aeromonas, Bordetella, Escherichia, Klebsiella, Pseudomonas |
| dfrB2 | − | dhfrIIb, dfr2b | 237 | J01773 | 809… 1045 | Escherichia |
| dfrB3 | − | dhfrIIc, dfr2c | 237 | X72585 | 5957… 6193 | Aeromonas, Enterobacter, Escherichia, Klebsiella |
| dfrB4 | − | dfr2d | 237 | AJ429132 | 69… 305 | Aeromonas, Escherichia, Klebsiella |
| dfrB5 | − | dfr2e | 237 | AY943084 | 2856… 3092 | Pseudomonas |
| dfrB6 | − | − | 237 | DQ274503 | 394… 630 | Salmonella |
| dfrB7 | − | − | 237 | DQ993182 | 244… 480 | Aeromonas |
| dfrB8 | − | − | 249 | GU295656 | 1048… 1296 | Aeromonas |
| dfrD | − | − | 489 | Z50141 | 94… 582 | Listeria, Staphylococcus |
| dfrG | − | − | 498 | AB205645 | 1013… 1510 | Enterococcus, Staphylococcus |
| dfrK | − | 492 | FM207105 | 2788… 3279 | Enterococcus, Staphylococcus |