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. 2012 Jul 5;15(2):17407. doi: 10.7448/IAS.15.2.17407

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© 2012 Peter D Kwong et al; licensee International AIDS Society

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Broadly neutralizing antibodies against HIV-1. The VRC01 antibody is capable of near pan-neutralization of HIV-1, which it achieves by recognition of the initial contact site of the CD4 receptor on HIV-1 gp120. (a) Neutralization dendrogram of VRC01. Strains of HIV-1 are displayed according to their genetic distance and coloured red, green and black according to their sensitivity to neutralization by VRC01 (Reproduced with permission from AAAS; Wu et al. [23]). (b) Recognition by VRC01. The surface of the gp120 glycoprotein is coloured grey for inner domain, red for outer domain and blue for bridging sheet region. The initial contact surface for CD4 is highlighted by yellow cross-hatching, and the recognition surface of VRC01 is shown in green. Note the concordance between VRC01 recognition and CD4 contact (Reproduced with permission from AAAS; Zhou et al. [26]).