Table 2.
Vaccines Effective in Small Animal Models. Comparison of current vaccine candidates at the small animal model level of development. Also listed are the afforded levels of immunization/protection, the type of vaccine used to induce immunity and the vaccination paradigm used to achieve the listed results.
| Vaccine | Type | Mechanism | Species Tested | Efficacy | Strategy |
|---|---|---|---|---|---|
| Ebola_VP30/Baculovirus | Virus-like particle (VLP) | Adaptive Immune Response | Mice | Drug dependent-up to 100% | Multiple i.m. injections multiple boosts |
| EBOV-GP-Fc fusion protein | Fusion protein/ subunit vaccine | Adaptive Immune Response | Mice | Up to 90% | 4 i.p. injections, ~3 weeks apart |
| Nicotiana Benthamiana | Subunit vaccine | Adaptive Immune Response | Mice | High specific antibody titer | 4 s.c. injections, 3 weeks apart |
| mCMV/EBOV-NPCTL | CMV-based vaccine | Adaptive Immune Response | Mice | Drug dependent-up to 100% | 2 i.p. injections, 4 weeks apart |
| HPIV3/ΔF-HN/EboGP | Vector-based vaccine, replication competent | Adaptive Immune Response | Guinea Pigs | 100% EBOV | 1 i.n. inoculation, 25 days prior to infection |