Table 4.

Post-Exposure Treatments Effective in Small Animal Models. Comparison of current treatment candidates at the small animal model level of development, specifically mouse models. Also listed are the afforded levels of protection, the type of drug used to induce immunity and the dosing paradigm used to achieve the listed results.

Drug	Type	Mechanism	Species Tested	Efficacy	Strategy
Mannose-binding Lectin	C-type Lectin	Binds to virus and mediates complement-dependent virus neutralization	Mice	40% (EBOV)	350 µg i.p. injection, twice daily for 10 days
Small-molecule inhibitors	Compound dependent	Compound dependent	Mice	Compound and dose dependent, ranging from 40%-100% (EBOV and MARV)	Single i.p. injection of 2-5 mg/kg between 1-3 days post-exposure
Hexamminecobalt (III) Chloride	Metal ion based drug	Inhibits viral replication	Mice	20% (EBOV)	Daily i.p. injections of 2-8 mg/kg