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. Author manuscript; available in PMC: 2012 Nov 16.
Published in final edited form as: Curr Opin Neurobiol. 2011 Jan 14;21(1):151–159. doi: 10.1016/j.conb.2010.12.002

Figure 2.

Figure 2

Neuronal activity regulates synaptic localization of surface Fz5. Under control condition, a fraction of surface Fz5 is present at synaptic sites labelled with vGlut1 and NR1. High frequency stimulation (HFS) promotes the trafficking of Fz5 to the cell surface and also its localization to synapses (arrows). Blockade of endogenous Wnts with the CRD domain of Fz5 suppresses the mobilization of Fz5 to the cell surface and to synapse. Remarkable, blockade of endogenous Wnts also suppresses activity-mediated synaptogenesis.