Table 1.
Molecular structures and physical and chemical properties of the ingredients
| Ingredient | Molecular structure | |
|---|---|---|
| ABT-102 |
|
|
| C21H24N4O | ||
| MW = 348.44 Tm = 225°C (under decomposition)a | ||
| State at RT: solid | ||
| LogP: 5.28a | ||
| Polysorbate 80/Tween 80 (nonionic surfactant) |
|
w + x + y + z = 20 |
| HLB: 15.429,30 | ||
| CMC: 15–16 μg/mL29,30 | ||
| State at RT: liquid | ||
| MW: 1310 g/mol | ||
| Sucrose palmitate/Surfhope D 1615 (nonionic surfactant) |
|
R = palmitate (80%) |
| HLB: 1531 | ||
| CMC: 0.002 mM32 | ||
| State at RT: solid | ||
| Tm: 54°C | x = 80; y = 27 | |
| MW: 579 g/mol | n/m = 60/40 | |
| Poloxamer 188/Lutrol F68 (block copolymer) |
|
|
| HLB: >2433 | ||
| CMC: 125 μM34 | ||
| State at RT: solid | ||
| Tm: 52°C33 | ||
| MW: ~8500 g/mol | ||
| PVP/VA 64/Kollidone 64 (polymer) |
|
|
| State at RT: solid | ||
| Tg: 101°C35 | ||
| MW: ~55,000 g/mol35 |
Note:
a
Abbott data.
Abbreviations: CMC, critical micelle concentration; HLB, hydrophilic/lipophilic balance; MW, molecular weight; RT, room temperature; Tg, glass transition temperature; Tm, melting point.