Figure 4.

Ex vivo ³¹P-MRS during 20 min global ischaemia and 30 min reperfusion in CrT-OE and wild-type hearts. (A) Phosphocreatine, PCr; (B) ATP; (C) inorganic phosphate, Pi; (D) intracellular pH, pHi; (E) free energy change of ATP hydrolysis, ΔG_ATP; (F) the myocardial glycogen content at baseline is 2.8-fold higher in CrT-OE mice (t-test, P = 0.003) and positively correlates with creatine levels. Data are mean ± SEM and P-value is for the effect of the genotype by two-way repeated measures ANOVA.