Table S1.
Function and regulation of eukaryotic small subunit ribosomal proteins
| Protein Name | Organism | Function | Reference | Find online at: |
|---|---|---|---|---|
| RPSA | Porcine | Candidate for binding and internalisation of externally added cellular prion protein in the gut | Knorr, C., Beuermann, C., Beck, J. and Brenig, B. (2007), 'Characterization of the porcine multicopy ribosomal protein SA/37-kDa laminin receptor gene family', Gene Vol. 395(1-2), pp. 135-143. | http://www.ncbi.nlm.nih.gov/pubmed/17434268 |
| RPS3A | Human | Cell apoptosis regulation | Naora, H. (1999), 'Involvement of ribosomal proteins in regulating cell growth and apoptosis: Translational modulation or recruitment for extraribosomal activity?', Immunol. Cell Biol. Vol. 77, pp. 197-205. | http://www.ncbi.nlm.nih.gov/pubmed/10361251 |
| RPS6 | Drosophila homologue of human S6 | Tumour suppressor in the haematopoietic system | Watson, K.L., Konrad, K.D., Woods, D.F. and Bryant, P.J. (1992), 'Drosophila homolog of the human S6 ribosomal protein is required for tumor suppression in the hematopoietic system. Proc. Natl. Acad. Sci. USA Vol. 89, pp. 11302-11306. | http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=50538 |
| RPS7 | Zebrafish | Mutations result in malignant peripheral nerve sheath tumour (zMPNST); RP genes may be 'haploinsufficient tumour suppressors' in zebrafish and cancer genes in humans | Amsterdam, A., Sadler, K.C., Lai, K., Farrington, S. et al. (2004), 'Many ribosomal protein genes are cancer genes in zebrafish', PLoS Biol. Vol. 2, p. E139. | http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371%2Fjournal.pbio.0020139&ct=1 |
| RPS8 | Zebrafish | Mutations result in malignant peripheral nerve sheath tumour (zMPNST); RP genes may be 'haploinsufficient tumour suppressors' in zebrafish and cancer genes in humans | Amsterdam, A., Sadler, K.C., Lai, K., Farrington, S. et al. (2004), 'Many ribosomal protein genes are cancer genes in zebrafish', PLoS Biol. Vol. 2, p. E139. | http://biology.plosjournals.org/perlserv/?request=get-document &doi=10.1371%2Fjournal.pbio.0020139&ct=1 |
| RPS9 | Human | Involved in retinal formation | Uechi, T., Tanaka, T. and Kenmochi, N. (2001), 'Complete map of the human ribosomal protein genes: Assignment of 80 genes to the cytogenetic map and implications for human disorders', Genomics Vol. 72, pp. 223-230. | http://www.ncbi.nlm.nih.gov/pubmed/11401437 |
| RPS10 | Arabidopsis thaliana | Developmental regulation | Majewski, P., Wołoszyńska, M. and Janńska, H. (2009), 'Developmentally early and late onset of Rps10 silencing in Arabidopsis thaliana: Genetic and environmental regulation', J. Exp. Bot. Vol. 60, pp. 1163-1178. | http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2657537&tool=pmcentrez |
| RPS13 | Human | Cell growth or proliferation regulation | Lai, M.D. and Xu, J. (2007), 'Ribosomal proteins and colorectal cancer', Curr. Genomics Vol. 8, pp. 43-49. | http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2474683 |
| RPS15 | Drosophila | Overexpression of S15a suppresses a utation in the Saccharomyces cerevisiae cdc33 gene, which encodes the cap-binding subunit of eukaryotic initiation factor 4F (eIF-4F); mutations of cdc33 lead to arrest in the cell cycle at the G1 to S transition. | Saeboe-Larssen, S. and Lambertsson, A. (1996), 'A novel Drosophila Minute locus encodes ribosomal protein S13', Genetics Vol. 143, pp. 877-885. | http://www.genetics.org/cgi/reprint/143/2/877 |
| Human | Role in nuclear export of 40S subunit precursors | Gazda, H., Sheen, M.R., Vlachos, A., Choesmel, V. et al. (2008), 'Ribosomal protein L5 and L11 mutations are associated with cleft palate and abnormal thumbs in Diamond-Blackfan anemia patients', Am. J. Hum. Genet. Vol. 83, pp. 769-780. | http://www.ncbi.nlm.nih.gov/pubmed/19061985 | |
| RPS15A | Zebrafish | Mutations result in malignant peripheral nerve sheath tumour (zMPNST); RP genes may be 'haploinsufficient tumour suppressors' in zebrafish and cancer genes in humans | Amsterdam, A., Sadler, K.C., Lai, K., Farrington, S. et al. (2004), 'Many ribosomal protein genes are cancer genes in zebrafish', PLoS Biol. Vol. 2, p. E139. | http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=406397 |
| RPS18 | Arabidopsis thaliana | Developmental regulation | Lai, M.D. and Xu, J. (2007), 'Ribosomal proteins and colorectal cancer', Curr. Genomics Vol. 8, pp. 43-49. | http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2474683 |
| Arabidopsis thaliana | Mutation in S18 associated with growth retardation and abnormal leaf development | Naora, H. (1999), 'Involvement of ribosomal proteins in regulating cell growth and apoptosis: Translational modulation or recruitment for extraribosomal activity?', Immunol. Cell Biol. Vol. 77, pp. 197-205. | http://www.ncbi.nlm.nih.gov/pubmed/10361251 | |
| Zebrafish | Mutations result in malignant peripheral nerve sheath tumour (zMPNST); RP genes may be 'haploinsufficient tumour suppressors' in zebrafish and cancer genes in humans | Amsterdam, A., Sadler, K.C., Lai, K., Farrington, S. et al. (2004), 'Many ribosomal protein genes are cancer genes in zebrafish', PLoS Biol. Vol. 2, p. E139. | http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=406397 | |
| RPS19 | Ascaris lumbricoides | Developmental regulation | Lai, M.D. and Xu, J. (2007), 'Ribosomal proteins and colorectal cancer', Curr. Genomics Vol. 8, pp. 43-49. | http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2474683 |
| Human | Tumour progression, invasion, metastasis, differentiation' | Lai, M.D. and Xu, J. (2007), 'Ribosomal proteins and colorectal cancer', Curr. Genomics Vol. 8, pp. 43-49. | http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2474683 | |
| Human | Degeneration of retina | Uechi, T., Tanaka, T. and Kenmochi, N. (2001), 'Complete map of the human ribosomal protein genes: Assignment of 80 genes to the cytogenetic map and implications for human disorders', Genomics Vol. 72, pp. 223-230. | http://www.ncbi.nlm.nih.gov/pubmed/11401437 | |
| Human | Dimer acts as a monocyte chemotactic factor in phagocytic clearance of apoptotic cells | Naora, H. (1999), 'Involvement of ribosomal proteins in regulating cell growth and apoptosis: Translational modulation or recruitment for extraribosomal activity?', Immunol. Cell Biol. Vol. 77, pp. 197-205. | http://www.ncbi.nlm.nih.gov/pubmed/10361251 | |
| Zebrafish | Haematopoietic and developmental abnormalities | Danilova, N., Sakamoto, K.M. and Lin, S. et al. (2008), 'Ribosomal protein S19 deficiency in zebrafish leads to developmental abnormalities and defective erythropoiesis through activation of p53 protein family', Blood Vol. 112, pp. 5228-5537. | http://www.ncbi.nlm.nih.gov/pubmed/18515656 | |
| RPS20 | Yeast | Overexpression of S20 suppresses temperature-sensitive RNA pol III (but no specificity?) | Hermann-Le Denmat, S., Sipiczki, M. and Thuriaux, P. (1994), 'Suppression of yeast RNA polymerase III mutations by the URP2 gene encoding a protein homologous to the mammalian ribosomal protein S20', J. Mol. Biol. Vol. 240, pp. 1-7. | http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WK7-45PV6 2P-1S&_user=4887109&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000062864&_version=1&_urlVersion=0&_userid=4887109&md5=88a77e1986 f7765e9374d649cc9b23a8 |
| Human | mRNA downregulated in onset of apoptosis in leukaemic cells | Naora, H. (1999), 'Involvement of ribosomal proteins in regulating cell growth and apoptosis: Translational modulation or recruitment for extraribosomal activity?', Immunol. Cell Biol. Vol. 77, pp. 197-205. | http://www.ncbi.nlm.nih.gov/pubmed/10361251 | |
| RPS21 | Drosophila | Acts as a translation initiation factor rather than as a core ribosomal protein | Török, I., Herrmann-Horle, D., Kiss, I., Tick, G. et al. (1999), 'Down-regulation of RpS21, a putative translation initiation factor interacting with P40, produces viable minute imagos and larval lethality with overgrown hematopoietic organs and imaginal discs', Mol. Cell Biol. Vol. 19, pp. 2308-2321. | http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=84023&tool=pmcentrez |
| RPS27A | Human | Cell growth or proliferation regulation | Ye, J.L. and Zhang, Y.Z. (2007), 'The connection between tumor and ubiquitin-ribosomal protein S27a, ubiquitin and ribosomal protein', Sheng Wu Gong Cheng Xue Bao Vol. 23, pp. 982-988. [Article in Chinese] | http://www.ncbi.nlm.nih.gov/pubmed/18257223?ordinalpos=5&itool=EntrezSystem2.PEntrez. Pubmed.Pubmed_Results Panel.Pubmed_DefaultReport Panel.Pubmed_RVDocSum |
| Human | Cell growth or proliferation regulation | Lai, M.D. and Xu, J. (2007), 'Ribosomal proteins and colorectal cancer', Curr. Genomics Vol. 8, pp. 43-49. | http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2474683 | |
| Human | Cell malignant transformation | Ye, J.L. and Zhang, Y.Z. (2007), 'The connection between tumor and ubiquitin-ribosomal protein S27a, ubiquitin and ribosomal protein', Sheng Wu Gong Cheng Xue Bao Vol. 23, pp. 982-988. [Article in Chinese] | http://www.ncbi.nlm.nih.gov/pubmed/18257223?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum | |
| RPS28 | Yeast | Binds to the 3' UTR of its mRNA to stimulate its deadenylation and degradation | Badis, G., Saveanua, C., Fromont-Racinea, M. and Jacquie, A. (2004), 'Targeted mRNA degradation by deadenylation-independent decapping', Mol. Cell Vol. 15, pp. 5-15. | http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WSR-4CRXKG3-3&_user=4887109&_rdoc=1&_fmt=&_orig=search &_sort=d&view=c&_acct=C000062864&_version=1&_urlVersion=0&_userid=4887109&md5=9b5ba025da819e725850644ba547d47c |
| RPS29 | Human | Tumour suppression gene regulation | Lai, M.D. and Xu, J. (2007), 'Ribosomal proteins and colorectal cancer', Curr. Genomics Vol. 8, pp. 43-49. | http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2474683 |
| Human | Increases tumour supporessor activity of Krev-1' | Naora, H. (1999), 'Involvement of ribosomal proteins in regulating cell growth and apoptosis: Translational modulation or recruitment for extraribosomal activity?', Immunol. Cell Biol. Vol. 77, pp. 197-205. | http://www.ncbi.nlm.nih.gov/pubmed/10361251 | |
| Zebrafish | Mutations result in malignant peripheral nerve sheath tumour (zMPNST); RP genes may be 'haploinsufficient tumour suppressors' in zebrafish and cancer genes in humans | Amsterdam, A., Sadler, K.C., Lai, K., Farrington, S. et al. (2004), 'Many ribosomal protein genes are cancer genes in zebrafish', PLoS Biol. Vol. 2, p. E139. | http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=406397 | |
Date last accessed for all websites is 17th June, 2010