Table S2.
Function and regulation of eukaryotic large subunit ribosomal proteins
| Protein Name | Organism | Function | Reference | Find online at |
|---|---|---|---|---|
| RPL4 | Rat | Required for rapid neurite regeneration | Twiss, J.L., Smith, D.S., Chang, B. and Shooter, E.M. (2000), 'Translational control of ribosomal protein L4 mRNA is required for rapid neurite regeneration', Neurobiol. Dis. Vol. 7, pp. 416-428. | http://www.ncbi.nlm.nih.gov/pubmed/10964612 |
| S. cerevisiae | Binds to single-stranded RNA/DNA | Cusick, M.E. (1994), 'Purification and identification of two major single-stranded binding proteins of yeast Saccharomyces cerevisiae as ribosomal protein L4 and histone H2B', Biochim. Biophys. Acta. Vol. 1217, pp. 31-40. | http://www.ncbi.nlm.nih.gov/pubmed/8286414 | |
| RPL7A | Human | Part of chimeric protein encoded by trk-2h oncogene | Ziemiecki, A., Müller, R.G., Fu, X.C., Hynes, N.E. et al. (1990), 'Oncogenic activation of the human trk proto-oncogene by recombination with the ribosomal large subunit protein L7a', EMBO J. Vol. 9, pp. 191-196. | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC551645/ |
| Zebrafish | Categorised as an ocular gene; downregulated in eyeless masterblind zebrafish. | Wang, H., Kesinger, J.W., Zhou, Q., Wren, J.D. et al. (2008), 'Identification and characterization of zebrafish ocular formation genes', Genome Vol. 51, pp. 222-235. | http://www.ncbi.nlm.nih.gov/pubmed/18356958 | |
| RPL7 | Human | Coregulator of vitamin D receptor-retinoid X receptor-mediated transactivation of genes | Berghöfer-Hochheimer, Y., Zurek, C., Wölfl, S., Hemmerich, P. et al. (1998), 'L7 protein is a coregulator of vitamin D receptor-retinoid X receptor-mediated transactivation', J. Cell. Biochem. Vol. 69, pp. 1-12. | http://www.ncbi.nlm.nih.gov/pubmed/9513041 |
| Rana sylvatica | Upregulated under freezing conditions | Wu, S., De Croos, J.N. and Storey, K.B. (2008), 'Cold acclimation-induced up-regulation of the ribosomal protein L7 gene in the freeze tolerant wood frog, Rana sylvatica', Gene Vol. 424, pp. 48-55. | http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T39-4T3DCV0-1&_user=4887109&_coverDate=11%2F15%2F2008&_rdoc=1&_fmt=high&_orig=search&_sort=d&_docanchor=&view=c&_searchStrId=1246451135&_rerunOrigin=google&_acct=C000062864&_version=1&_urlVersion=0&_userid=4887109&md5=4e11f74a6e6a29fe16aa172087195d0d | |
| RPL10 | Arabidopsis | A component of the NIK-mediated antiviral signaling | Rocha, C.S., Santos, A.A., Machado, J.P. and Fontes, E.P. (2008), 'The ribosomal protein L10/QM-like protein is a component of the NIK-mediated antiviral signaling', Virology Vol. 380, pp. 165-169. | http://www.ncbi.nlm.nih.gov/pubmed/18789471 |
| RPL13 | Hamster cells | Upregulated in response to DNA damage | Kobayashi, T., Sasaki, Y., Oshima, Y., Yamamoto, H. et al. (2006), 'Activation of the ribosomal protein L13 gene in human gastrointestinal cancer', Int. J. Mol. Med. Vol. 18, pp. 161-170. | http://www.ncbi.nlm.nih.gov/pubmed/16786168 |
| RPL22 | Mammals | Identical to heparin-binding protein, HBp15 | Fujita, Y., Okamoto, T., Noshiro, M., McKeehan, W.L. et al. (1994), 'A novel heparin-binding protein, HBp15, is identified as mammalian ribosomal protein L22', Biochem. Biophys. Res. Commun. Vol. 199, pp. 706-713. | http://www.ncbi.nlm.nih.gov/pubmed/8135813 |
| Drosophila | Interacts with casein kinase II | Zhao, W., Bidwai, A.P. and Glover, C.V. (2002), 'Interaction of casein kinase II with ribosomal protein L22 of Drosophila melanogaster', Biochem. Biophys. Res. Commun. Vol. 298, pp. 60-66. | http://www.ncbi.nlm.nih.gov/pubmed/12379220 | |
| Human | Binds Epstein-Barr virus (EBV)-encoded RNA (EBER) in EBV-infected cells | Le, S., Sternglanz, R. and Greider, C.W. (2000), 'Identification of two RNA-binding proteins associated with human telomerase RNA', Mol. Biol. Cell Vol. 11, pp. 999-1010. | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC14826/ | |
| Human | Binds human telomerase RNA | Le, S., Sternglanz, R. and Greider, C.W. (2000), 'Identification of two RNA-binding proteins associated with human telomerase RNA', Mol. Biol. Cell Vol. 11, pp. 999-1010. | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC14826/ | |
| RPL23A | Human | May play a role in growth inhibition | Jiang, H., Lin, J.J., Tao, J. and Fisher, P.B. (1997), 'Suppression of human ribosomal protein L23A expression during cell growth inhibition by interferon-beta', Oncogene Vol. 14, pp. 473-480. | http://www.nature.com/onc/journal/v14/n4/abs/1200858a.html |
| RPL24 | Arabidopsis | Gynoecium development | Nishimura, T., Wada, T. and Okada, K. (2004), 'A key factor of translation reinitiation, ribosomal protein L24, is involved in gynoecium development in Arabidopsis', Biochem. Soc. Trans. Vol. 32, pp. 611-613. | http://www.ncbi.nlm.nih.gov/pubmed/15270688?dopt=Abstract |
| Marine shrimp | Differential expression in gonads | Zhang, Z., Wang, Y., Jiang, Y., Lin, P. et al. (2007), 'Ribosomal protein L24 is differentially expressed in ovary and testis of the marine shrimp Marsupenaeus japonicus', Comp. Biochem. Physiol. B Biochem. Mol. Biol. Vol. 147, pp. 466-474. | http://www.ncbi.nlm.nih.gov/pubmed/17462931 | |
| RPL35A | Human | Cell death inhibition | Lopez, C.D., Martinovsky, G. and Naumovski, L. (2002), 'Inhibition of cell death by ribosomal protein L35a', Cancer Lett. Vol. 180, pp. 195-202. | http://www.ncbi.nlm.nih.gov/pubmed/12175552 |
| RPP0 | Human | Interacts with GCIP, and over-expression in breast and liver cancer results in cell proliferation | Chang, T.W., Chen, C.C., Chen, K.Y., Su, J.H. et al. (2008), 'Ribosomal phosphoprotein P0 interacts with GCIP and overexpression of P0 is associated with cellular proliferation in breast and liver carcinoma cells', Oncogene Vol. 27, pp. 332-338. | http://www.ncbi.nlm.nih.gov/pubmed/17621266 |
| RPLP1 | Mouse | Over-expression leads to cell proliferation of mouse embryonic fibroblasts | Artero-Castro, A., Kondoh, H., Fernández-Marcos, P.J., Serrano, M. et al. (2009), 'Rplp1 bypasses replicative senescence and contributes to transformation', Exp. Cell Res. Vol. 315, pp. 1372-1383. | http://www.ncbi.nlm.nih.gov/pubmed/19233166 |
| MRPL41 | Human and mice | Suppresses cell growth | Yoo, Y.A., Kim, M.J., Park, J.K., Chung, Y.M. et al. (2005), 'Mitochondrial ribosomal protein L41 suppresses cell growth in association with p53 and p27Kip1', Mol. Cell. Biol. Vol. 25, pp. 6603-6616. | http://www.ncbi.nlm.nih.gov/pubmed/16024796 |
Date last accessed for all websites is 17th June, 2010