Table 3.

Relevant pharmacogenetics association studies that have focused on catechol-O-methyl transferase (COMT)

Reference	Gene	Drug	Sample	Outcome measure	Results	p-value
[24]	COMT	Bupropion	553 smokers	Weight gain after smoking cessation	TC genotype at the C957T locus was associated with increased weight gain at six months of follow-up; however, no polymorphisms, or their interactions with bupropion, consistently and significantly predicted baseline BMI or weight change	Not significant
[25]	COMT	Various	346 MDD patients	HAMD	There was a small effect with citalopram treatment (Val(108/158)Met)	p = 0.007 (gene per time interaction)
[26]	COMT	Mirtazapine and paroxetine	102 MDD patients	HAMD	COMT polymorphism Val(108/158)Met influenced mirtazapine but not paroxetine response	p = 0.011

Abbreviations: MDD, major depressive disorder; BMI, body mass index; COMT, catechol-O-methyl transferase; HAMD, Hamilton Rating Scale for Depression