Table 3.
Comparison of differential expression in human and doga
| Comparison | Totalb | Replicated | Consistent | Questionable | Opposite |
|---|---|---|---|---|---|
| Cerebellum > pituitary | 403 | 8 | 7 | 5 | 1 |
| Cortex > pituitary | 453 | 8 | 4 | 9 | 3 |
| Cerebellum > cortex | 175 | 3 | 3 | 1 | 0 |
| Cortex > cerebellum | 286 | 0 | 4 | 4 | 1 |
a Genes differentially expressed in humans showing the same direction of effect in dogs that is significant at p < 0.05 (replicated), non-significant (consistent), no change or non-significant in the opposite direction (questionable), or significant in the opposite direction.
b The total number of Affymetrix probe-sets reported as being more than two-fold higher in the first tissue than the mean of all other tissues, and less than the mean of all others in the second tissue, from the Novartis website [29]. Only around 5 per cent of these probe-sets have unambiguous orthologues in this canine cDNA array. Too few pituitary-specific human genes were detected on the canine array to report a contrast.