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. 2012 Aug 15;12:354. doi: 10.1186/1471-2407-12-354

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Copyright ©2012 Van den broeck et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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A SP is present in human PDAC. (A) Hematoxylin-Eosin staining of an original PDAC sample (left) and the corresponding xenograft tumour (right). A representative example is shown. Scale bar = 50 μm. (B) SP identification by FACS (left) and control of the SP phenotype with verapamil (right). A representative example with SP proportions is displayed. Inserts show a SP cell (left) and a MP cell (right) after Cyto Rich Red staining. Scale bar = 1 μm. (C) Boxplot of the SP proportion, with and without verapamil, of all PDAC xenografts analyzed (n = 17). *, p < 0.05. (D) Analysis of CD45 and CD31 expression in the PDAC xenograft SP using FACS. A representative example is shown. Numbers represent the percentage of CD45⁺ cells and of CD31⁺ cells within the SP.