Table 1.
PXS-associated genes and associated polymorphic markers
| PXS associated gene | Chromosome | Associated polymorphic marker |
|---|---|---|
| LOXL1 gene
[28,29,32-34,77-80] |
15q24.1 |
rs2165241 |
| rs3825942 | ||
| rs1048661 | ||
| Clusterin gene
[14] |
8p21 |
rs3087554 |
| Glutathione transferase gene
[51,56,57] |
1p13.3 |
M0 and T0 genotype |
| CNTNAP2 gene
[58] |
7q35 |
rs2107856 |
| rs2141388 | ||
| TNF α G-308A polymorphism
[62,65,67] |
6p21 |
rs1800629 |
| rs361525 | ||
| Blood group B [68] | 9q34 |
*Reported frequencies are for the rs1048661 T allele which is the high risk allele in the Japanese cohort.