Table 2.

LOXL 1 SNPs high risk allele frequencies in different populations

Population	Group	Cohort size	rs3825942 G	Odds ratio (OR)	Pvalue	rs1048661 G	Odds ratio (OR)	P value	Reference
			Allele frequency			Allele frequency
Iceland	Control	14,474	0.847			0.651			[28]
	PXS	55	0.982	10.10 (4.02 – 25.36)	8.5 × 10−7	0.789	2.02 (1.32 – 3.09)	1.3 × 10−3
	PXG	75	0.987	13.23 (5.59 – 31.29)	4. × 10−9	0.827	2.56 (1.74 – 3.77)	1.8 × 10−6
Sweden	Control	198	0.879			68			[28]
	PXS	NA	NA			NA
	PXG	199	0.995	27.28 (11.44 – 65.07)	9.1 × 10−14	0.834	2.39 (1.72 – 3.34)	2.7 × 10−7
USA	Control	235	0.844			0.665			[34]
	PXS		NA			NA
	PXG	50	0.939	3.05(1.20 – 7.76)	0.0194	0.787	1.86(1.10, 3.15)	0.0222
India	Control	97	0.74			0.63			[30]
	PXS and PXG	52	0.92		0.0001	0.72		0.156
Japan	Control	172	0.863			0.503*
	PXS	103	0.985	10.71 (3.29 – 34.87)	1.49 *10−7	0.932*	13.56 (7.57 – 24.27)	3.39 *10−28	[29]
	PXG	106	0.986	11.02 (3.39 – 35.9)	1.40 *10−7	0.962*	25.21 (12.06 – 52.69)	1.44* 10−34
Chinese	Control	171	0.918			0.444
	PXS and PXG	62	0.992	1.92 (1.25 – 2.96)	0.0034	0.524	1.92 (1.25 – 2.96)	0.0034	[77]
German	Control	348	0.857			0.644
	PXS	206	0.948	3.06 (1.87 – 4.99)	3.15 *10−6	0.787	2.04 (1.54 – 2.71)	7.08 * 10−7	[78]
	PXG	311	0.953	3.41 (2.22 – 5.24)	4.78 *10−9	0.839	2.89 (2.21 – 3.77)	1.40 *10−15
Italian	Control	70	0.821			0.693
	PXS	76	1.000	∞	5.08 *10−8	0.842	2.36 (1.34 – 4.16)	0.0024	[78]
	PXG	133	1.000	∞	1.96 *10−12	0.815	1.96 (1.22 – 3.15)	0.0053
Australian	Control	86	0.84			0.66
	PXS	335	0.95	3.81 (1.88 – 9.02)	7.83*10−5	0.78	1.86 (1.27 – 2.76)	8.49*10−4	[79]
	PXG		NA			NA
Saudi	Control	101	0.817			0.762			[80]
	PXS	NA	NA			NA
	PXG	93	0.968		0.000005	0.876		0.0056