Table 2.
DNA damage in the exposed subjects with different genotypes of polymorphisms
| SNP | genotype | n |
Olive tail moment |
Tail length |
Tail DNA% |
|||
|---|---|---|---|---|---|---|---|---|
| Median | P25-P75 | Median | P25-P75 | Median | P25-P75 | |||
| XRCC1 Arg399Gln |
GG |
70 |
0.93 |
0.58–1.79 |
9.74 |
6.89–18.14 |
3.25 |
1.94–5.58 |
| GA |
42 |
0.73 |
0.46–1.35 |
8.19 |
5.93–13.79 |
2.50 |
1.77–4.36 |
|
| AA |
8 |
0.50 |
0.43–0.93 |
6.64 |
5.00–9.92 |
1.91 |
1.43–3.03 |
|
| |
P* |
|
0.048 |
0.050 |
0.039 |
|||
| |
AA + GA |
50 |
0.66 |
0.44–1.31 |
8.00 |
5.69–13.74 |
2.32 |
1.66–4.33 |
| |
P∮ |
|
0.043 |
0.067 |
0.046 |
|||
| XRCC1 Arg194Trp |
CC |
66 |
0.75 |
0.47–1.45 |
8.55 |
6.30–14.22 |
2.82 |
1.66–4.85 |
| CT |
49 |
0.91 |
0.48–1.49 |
9.69 |
6.97–16.25 |
3.22 |
1.83–4.75 |
|
| TT |
5 |
0.66 |
0.37–1.82 |
7.67 |
5.11–16.94 |
2.39 |
1.29–5.84 |
|
| |
P* |
|
0.973 |
0.964 |
0.992 |
|||
| OGG1 Ser326Cys |
CC |
18 |
1.09 |
0.41–1.84 |
11.72 |
4.92–18.87 |
3.63 |
1.55–5.80 |
| CG |
56 |
0.86 |
0.47–1.46 |
9.18 |
6.50–15.53 |
3.07 |
1.73–4.86 |
|
| GG |
41 |
0.78 |
0.56–1.19 |
8.93 |
6.87–12.07 |
2.69 |
2.02–4.15 |
|
| |
P* |
|
0.462 |
0.335 |
0.377 |
|||
| ERCC1 C8092A |
CC |
20 |
0.84 |
0.45–1.38 |
9.79 |
6.56–15.53 |
3.20 |
1.77–4.72 |
| CA |
47 |
0.71 |
0.47–1.43 |
8.10 |
5.81–14.10 |
2.45 |
1.61–4.53 |
|
| AA |
49 |
0.92 |
0.62–1.60 |
9.66 |
7.21–17.29 |
3.22 |
2.06–5.50 |
|
| |
P* |
|
0.543 |
0.690 |
0.595 |
|||
| ERCC5 His1104Asp |
GG |
25 |
0.92 |
0.62–1.60 |
9.66 |
7.21–17.29 |
3.22 |
2.06–5.50 |
| GC |
61 |
0.84 |
0.54–1.50 |
9.66 |
6.79–15.88 |
2.84 |
1.99–4.99 |
|
| CC |
30 |
0.83 |
0.50–1.38 |
9.21 |
7.01–15.05 |
3.04 |
1.81–4.59 |
|
| |
P* |
|
0.886 |
0.931 |
0.920 |
|||
| ERCC6 Gly399Asp |
CC |
32 |
0.83 |
0.49–1.14 |
8.90 |
6.82–11.70 |
3.03 |
1.87–3.97 |
| CT |
54 |
0.75 |
0.48–1.73 |
8.26 |
6.42–16.12 |
2.75 |
1.85–5.51 |
|
| TT |
31 |
1.03 |
0.48–1.57 |
10.70 |
5.72–18.10 |
3.22 |
1.68–5.19 |
|
| |
P* |
|
0.143 |
0.152 |
0.203 |
|||
| XPD Lys751Gln |
AA |
94 |
0.82 |
0.48–1.45 |
9.50 |
6.42–14.84 |
2.94 |
1.81–4.80 |
| AC |
20 |
0.81 |
0.48–1.81 |
8.79 |
7.00–16.74 |
2.88 |
1.88–5.81 |
|
| CC |
0 |
|
|
|
|
|
|
|
| |
P* |
|
0.771 |
0.742 |
0.900 |
|||
| XPC Lys939Gln |
GG |
45 |
0.89 |
0.56–1.52 |
9.66 |
6.97–15.96 |
2.96 |
2.02–5.14 |
| GT |
53 |
0.83 |
0.47–1.40 |
8.87 |
6.63–14.07 |
2.75 |
1.39–6.13 |
|
| TT |
18 |
0.81 |
0.39–2.10 |
9.13 |
5.68–23.00 |
2.92 |
1.73–4.57 |
|
| |
P* |
|
0.564 |
0.379 |
0.705 |
|||
| GSTP1 Ile105Val |
AA |
80 |
0.83 |
0.52–1.58 |
9.21 |
6.75–15.65 |
2.94 |
1.85–5.30 |
| AG |
30 |
0.70 |
0.38–1.41 |
8.03 |
5.71–15.29 |
2.41 |
1.62–4.53 |
|
| GG |
6 |
1.02 |
0.71–1.84 |
11.89 |
8.83–18.95 |
3.74 |
2.46–5.83 |
|
| P* | 0.169 | 0.514 | 0.463 | |||||
* The DNA damage data was square root-transformed and multivariable linear model was used after adjusting confounding factors of gender, age, smoking status, drinking and exposure time of chromium.
Comparing the subjects with GG genotype with AA + GA.
∫ Owing to missing detect in DNA damage and genotype, the numbers of subjects in Table 2 were less 157 in exposed group.