Figure 4. OXPHOS defects inhibit fusion with wild-type mitochondria in trans.

Wild-type and mutant cells expressing matrix-targeted mtGFP or mtRFP were conjugated and mitochondrial fusion was analyzed by fluorescence microscopy after the indicated times (A, B) or after 4 hours (C). A: Kinetics of Total (T), Partial (P) and No fusion (N). B, C: Comparison of total fusion as a function of time (B) or of Total, Partial and No fusion after 4 hours (C). Dashed line: proportion of fusion in wild-type cells.