Table 1. Defining the sixteen latent classes and calculating their sero-prevalence rates.
Class No. | Latent class definition | Seroprevalence | |
Median (95% CI)* | Mean | ||
Class 1 | Mtb**+, All antibodies+ | 15.9 (9.8, 24.0) | 16.2 |
Class 2 | Mtb+, ESAT6+, CFP10+, PE-PGRS11+ | 1.3 (0.1, 4.3) | 1.5 |
Class 3 | Mtb+, ESAT6+, CFP10+, PE-PGRS17+ | 0.4 (0.0, 2.1) | 0.6 |
Class 4 | Mtb+, ESAT6+, PE-PGRS11+, PE-PGRS17+ | 0.8 (0.0, 4.4) | 1.2 |
Class 5 | Mtb+, CFP10+, PE-PGRS11+, PE-PGRS17+ | 3.1 (0.2, 10.3) | 3.7 |
Class 6 | Mtb+, ESAT6+, CFP10+ | 0.8 (0.0, 3.2) | 1.0 |
Class 7 | Mtb+, ESAT6+, PE-PGRS11+ | 0.6 (0.0, 3.2) | 0.9 |
Class 8 | Mtb+, ESAT6+, PE-PGRS17+ | 0.5 (0.0, 2.3) | 0.7 |
Class 9 | Mtb+, CFP10+, PE-PGRS11+ | 0.5 (0.0, 2.6) | 0.7 |
Class 10 | Mtb+, CFP10+, PE-PGRS17+ | 0.4 (0.0, 2.3) | 0.6 |
Class 11 | Mtb+, PE-PGRS11+, PE-PGRS17+ | 11.9 (4.2, 18.5) | 11.7 |
Class 12 | Mtb+, ESAT6+ | 0.7 (0.0, 3.5) | 1.0 |
Class 13 | Mtb+, CFP10+ | 0.5 (0.0, 2.6) | 0.7 |
Class 14 | Mtb+, PE-PGRS11+ | 0.7 (0.0, 3.1) | 0.9 |
Class 15 | Mtb+, PE-PGRS17+ | 4.8 (0.2, 11.8) | 5.1 |
Class 16 | Mtb-, All antibodies- | 53.6 (44.6, 62.8) | 53.6 |
Latent class definition and the seroprevalence rate for each class thus defined in the LCA model for studying TB in Asian elephants in southern India. The latent classes are different combinations of the latent variables (i.e. true presence of the antibodies) which are present if M. tuberculosis infection is present. *Median estimate is at the 50% quantile while the 2.5% and 97.5% quantiles define a 95% credible interval (CI). **M. tuberculosis infection.