Table 2. Sensitivity (DSe) and specificity (DSp) of the five serological tests used in the study.
Test | w.r.t.** | DSe | DSp |
Median (95% CI)* | Median (95% CI)* | ||
RT | At least 1 antibody | 48.6 (37.2, 61.0) | 99.3 (96.7, 99.9) |
ESAT6 | 44.6 (33.9, 56.4) | 95.2 (90.4, 98.2) | |
CFP10 | 46.5 (36.0, 58.1) | 93.0 (87.8, 96.6) | |
PE_PGRS11 | 79.8 (66.7, 90.8) | 98.5 (93.6, 99.9) | |
PE_PGRS17 | 84.5 (75.2, 91.3) | 89.6 (79.4, 98.4) | |
ESAT6 | At least 1 antibody | 88.8 (73.5, 97.5) | 95.1 (90.5, 98.2) |
ESAT6 | 91.3 (74.8, 99.5) | 95.2 (90.4, 98.2) | |
CFP10 | 77.0 (61.9, 88.5) | 88.9 (83.2, 93.6) | |
PE_PGRS11 | 85.0 (71.7, 94.0) | 75.9 (68.2, 82.3) | |
PE_PGRS17 | 80.3 (66.7, 90.2) | 65.7 (57.8, 73.1) | |
CFP10 | At least 1 antibody | 88.8 (73.5, 97.5) | 95.3 (90.8, 98.2) |
ESAT6 | 75.2 (60.0, 87.1) | 91.2 (85.7, 95.2) | |
CFP10 | 92.3 (76.9, 99.5) | 93.0 (87.8, 96.6) | |
PE_PGRS11 | 85.2 (71.5, 94.0) | 76.0 (68.5, 82.6) | |
PE_PGRS17 | 81.5 (67.9, 91.4) | 66.2 (58.3, 73.5) | |
PE_PGRS11 | At least 1 antibody | 50.1 (38.2, 62.1) | 93.9 (88.8, 97.2) |
ESAT6 | 47.1 (35.8, 58.7) | 91.5 (85.9, 95.4) | |
CFP10 | 49.1 (38.0, 60.2) | 89.4 (83.5, 93.7) | |
PE_PGRS11 | 97.6 (88.6, 99.8) | 98.5 (93.6, 99.9) | |
PE_PGRS17 | 87.1 (77.6, 93.6) | 81.4 (73.4, 88.1) | |
PE_PGRS17 | At least 1 antibody | 44.4 (32.5, 57.6) | 91.6 (85.5, 96.0) |
ESAT6 | 42.2 (30.9, 54.8) | 89.6 (83.0, 94.1) | |
CFP10 | 44.8 (33.6, 57.1) | 87.8 (81.5, 92.7) | |
PE_PGRS11 | 82.7 (68.2, 94.3) | 91.9 (85.3, 96.5) | |
PE_PGRS17 | 97.2 (88.5, 99.9) | 89.6 (79.4, 98.7) |
The LCA model was used to calculate the DSe and DSp of each test w.r.t. the antibody it is designed to detect as also presence of at least one antibody. *The Median estimate refers to the 50% quantile while the 2.5% and 97.5% quantiles define a 95% credible interval (CI). ** With respect to.