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. 2012 Nov 16;7(11):e49731. doi: 10.1371/journal.pone.0049731

Figure 1. Lentiviral gene constructs and clinical development of arthritis.

Figure 1

(A) Lentiviral constructs: LNT-GFP and LNT-IL-10. LTR; long terminal repeat, cPPT; central polypurine tract, pA; polyadenylic acid tail, WPRE; Woodchuck post-transcriptional regulatory element, IL-1E; Interleukin-1 enhancer, IL-6 promoter. (B) Severity of arthritis (mean arthritis score ± SEM). LNT-GFP (day 0–42 n = 18, day 44–49 n = 10) and LNT-IL-10 (day 0–42 n = 25, day 44–49 n = 14)). (C) Histopathological severity of synovitis and cartilage and bone erosivity measured as histological severity score (Y-axis) ranging from 0–3. Data in figure 1B and C were analysed by Mann-Whitney U-test. Closed circles represents LNT-GFP and open circles LNT-IL-10 mice. Bars in 1C represent the median.