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Synthesis of crizotinib. (A): Design and synthesis of crizotinib. Figure 3A provided by Jean Cui. Please refer to reference 107 for detailed synthesis of crizotinib. (B): Crystallography of crizotinib in unphosphorylated MET and ALK [108, 109]. PDB ID 2wgj for PF-02341066/c-MET complex; PDB ID 2xp2 for PF-02341066/ALK complex. Figure 3B provided Jean Cui.
Abbreviation: MW, molecular weight.
