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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Semin Cancer Biol. 2012 Jun 18;23(2):99–108. doi: 10.1016/j.semcancer.2012.06.008

Figure 2.

Figure 2

A) SC35 domains (green) in normal human skeletal in the euchromatin compartment are associated at their edges with many specific active genes (red), for example the DMPK gene. B) SC35 domains in pluripotent (1) hESCs are diffuse and begin to form only upon differentiation (2, 3) and finally exhibit the normal somatic distribution in fully differentiated cells (4) (Reprinted from [40]). C) SC35 domains in cancer cells (PC3, T47D) display a diffuse pattern of SC35 localization with less defined accumulations compared to normal cells, more similar to earlier differentiating ES cells (shown in B).