Skip to main content
. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Semin Cancer Biol. 2012 Jun 18;23(2):99–108. doi: 10.1016/j.semcancer.2012.06.008

Figure 4.

Figure 4

In normal human nuclei (A, B), a prominent rim of DNA (dark rim) lacking COT-1 RNA (white nucleoplasmic signal) apposed to the edge of the nucleus (white line) demonstrates a normal peripheral heterochromatic compartment. The heterochromatic compartment is visualized by RNA hybridization using a Cot-1 probe. Some cancer cells (below) have a much less prominent rim, indicating a compromise of this peripheral compartment. C) The outer edge of each nucleus is enlarged for each cell type. Reprinted from [72].