Skip to main content
. Author manuscript; available in PMC: 2013 Nov 15.
Published in final edited form as: Cancer Res. 2012 Sep 19;72(22):6002–6012. doi: 10.1158/0008-5472.CAN-12-0748

Figure 4. Rat Mcs1b resistant genotype is associated with higher body weight and rat/human Mier3/MIER3 levels are higher in rat mammary and human breast carcinomas.

Figure 4

Panel A: Lower body weight at 12 weeks of age was observed in mammary carcinoma susceptible (diamonds) compared to Mcs1b resistant females (squares) with DMBA and without (P < 0.0001 and P = 0.0007, respectively). Body weight was significantly higher in susceptible females that received DMBA compared to without (P < 0.0001). Panel B: Rat Mier3 transcript levels were significantly higher in DMBA-induced mammary carcinomas (triangles) compared to non-diseased mammary gland tissue (circles, P = 0.0120). Mean ± SD are graphed for each variable. Panel C: Human MIER3 was significantly higher in breast carcinomas compared to pathologically normal breast tissues. Oncomine (www.oncomine.org, reference 41 of main text) was used to query The Cancer Genome Atlas (cancergenome.nih.gov) gene expression database. Shown are box plots of log2 median centered MIER3 transcript levels for invasive ductal breast carcinomas (IDBC, n=392) and invasive lobular breast carcinomas (ILBC, n=36) compared to pathologically normal breast tissues (Breast, n=61). *P < 0.05. †P = 0.0569.