Table 3.

Analysis and Statistics of Mcs1b Potential Candidate Gene Mammary Gland Transcript Levels in Mcs1b Resistant and Susceptible Genotypes at Twelve Weeks of Age

	Two-Way ANOVA F-Test P-Values				Log2 Target/Rplp2 Mean ± SD (n)
Target	Mcs1b Genotype	Exposure	G X E	Exposure	Susceptible	Mcs1b Resistant	P value*
Gpbp1	0.0101	0.2090	0.6422	Control	0.586 ± 0.600 (34)	0.044 ± 0.734 (29)	0.0020
				DMBA	0.281 ± 1.309 (45)	−0.097 ± 1.246 (42)	0.1716
Mier3	0.0023	0.7911	0.6682	Control	0.115 ± 0.594 (34)	−0.522 ± 1.278 (34)	0.0104
				DMBA	0.154 ± 1.557 (45)	−0.688 ± 1.943 (48)	0.0240
Map3k1	0.0002	0.0003	0.0588	Control	−0.092 ± 0.818 (34)	−0.725 ± 0.767 (32)	0.0019
				DMBA	0.105 ± 0.564 (47)	−0.104 ± 0.651 (45)	0.1036
Ankrd55	0.4694	0.2025	0.9019	Control	−0.691 ± 0.678 (24)	−0.826 ± 1.108 (22)	0.6180
				DMBA	−0.377 ± 1.296 (17)	−0.567 ± 1.006 (22)	0.6090
Il6st	0.0199	0.1744	0.8435	Control	−0.066 ± 0.755 (36)	−0.418 ± 1.054 (33)	0.1137
				DMBA	0.189 ± 1.006 (44)	−0.227 ± 1.181 (48)	0.0734
Il31ra	0.2869	0.8674	0.9928	Control	−0.331 ± 1.072 (24)	−0.559 ± 0.761 (23)	0.4072
				DMBA	−0.368 ± 0.942 (20)	−0.592 ± 1.159 (23)	0.4949
Ddx4	0.0555	0.5442	0.4045	Control	−0.107 ± 0.983 (36)	−0.359 ± 0.911 (33)	0.2748
				DMBA	−0.055 ± 1.122 (18)	−0.690 ± 1.575 (17)	0.1769
Slc38a9	0.1008	0.3929	0.9730	Control	−0.285 ± 0.600 (24)	−0.575 ± 0.681 (23)	0.1284
				DMBA	−0.144 ± 0.970 (20)	−0.422 ± 0.954 (23)	0.3499
Ppap2a	0.3918	0.8314	0.5788	Control	−0.385 ± 0.632 (24)	−0.447 ± 0.765 (23)	0.7629
				DMBA	−0.315 ± 1.357 (20)	−0.605 ± 1.029 (23)	0.4315

Abbreviations: n, number of females; G, genotype; E, exposure; DMBA, 7,12-dimethylbenz[a]anthracene

^*Fisher’s PLSD test P values from comparing susceptible and Mcs1b resistant genotypes by exposure