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. Author manuscript; available in PMC: 2013 Nov 16.
Published in final edited form as: ACS Chem Biol. 2012 Sep 21;7(11):1822–1829. doi: 10.1021/cb300335j

Figure 3.

Figure 3

(a) Analytical size exclusion chromatography of MW standards (•), hCGL-NLV (□) and PEGylated hCGL-NLV (○). (b) Pharmacodynamics of PEG-hCGL-NLV in balb/c mice maintained on a Met(-)Hcyss(-)Chl(-) diet. Mice (n=5) were treated with 200 U PEG-hCGL-NLV administered by tail-vein injection and blood methionine level (○) was monitored by HPLC. (c) In vivo activity of PEG-hCGL-NLV (○) and unPEGylated hCGL-NLV (•) in serum as a function of time following tail-vein injection of 100U PEG-hCGL-NLV in athymic mice (n=5).