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. Author manuscript; available in PMC: 2013 Nov 15.
Published in final edited form as: Cancer Res. 2012 Aug 31;72(22):5833–5842. doi: 10.1158/0008-5472.CAN-12-1229

Figure 7. Working hypothesis of PROX1/LRH1-mediated inhibition of RGS4 expression to protect vGPCR activity for KS tumorigenesis.

Figure 7

Acting as aGTPase-activating protein (GAP)of cellular GPCRs, RGS4 can also antagonize KSHV viral GPCR activity. In order to ensure the maximum activity of vGPCR, KSHV-mediated upregulation of a nuclear receptor LRH1 and its interacting coregulator PROX1 leads to cooperative suppression of the expression of RGS4, a newly identified inhibitor of vGPCR.