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. Author manuscript; available in PMC: 2013 Nov 15.
Published in final edited form as: Cancer Res. 2012 Aug 6;72(22):5778–5789. doi: 10.1158/0008-5472.CAN-12-0603

Figure 1. IEC-specific PHB overexpression reduces colonic tumorigenesis in a mouse model of CAC.

Figure 1

Mice were intraperitoneally injected with azoxymethane (AOM) and 7 days later treated with two cycles of 3% DSS, each cycle consisting of 7 days DSS followed by 14 days of water recovery, and sacrificed on day 56 after AOM injection. (A) Percent change in body weight during each week of the CAC protocol. (B) Clinical score following DSS treatment. End 1st cycle DSS: n = 13 WT; n = 14 Tg. End 2nd cycle DSS: n = 12 WT; n = 14 Tg. (C) Percent survival. P = 0.146. (D) Number of polyps and size distribution of polyps as determined using a dissecting microscope. (E) Representative gross anatomy of the colon (upper panels) and representative colonoscopy images (lower panels) at the end of the CAC protocol. (F) Histopathology scores. *P < 0.05 vs. AOM DSS-treated WT.