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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Aging Cell. 2012 Oct 1;11(6):1017–1026. doi: 10.1111/acel.12002

Figure 2. Behavioral assessment of diabetic SAMR1 and SAMP8 mice.

Figure 2

T1D mice were assessed for locomotor and cognitive function beginning at nine months, one month prior to sacrifice. Distance traveled (A) and average velocity (B) of T1D mice were assessed in the open field test. There was a trend towards lower activity in the SAMP8 mice with significantly different velocities between the T1D SAMP8 mice and the SAMR1 control mice. (C) The fear conditioning test showed that SAMP8 mice had lower contextual freezing time, suggestive of impaired hippocampal-dependent associative learning. T1D had a similar effect in the SAMR1 mice but did not further exacerbate the decrease in the SAMP8 mice. *p<0.05, **p<0.01, ***p<0.001, One-way ANOVA followed by Newman-Keuls post-hoc test (n = 4–7/group). All data are mean ± SEM.