Figure 2.

Degranulation of NK cells with or without inhibition of KIR-HLA interaction. Target MLL-rearranged leukemia cells were left untreated or treated with 10 µg/mL of panMHCI antibody before co-culture with 10 U/mL IL-2 pretreated NK cells at a ratio of 2:1 (targets to effectors) for 5 h. The percentages of CD107a⁺ KIR2DL1, KIR2DL2/3, and KIR3DL1 subsets of NK cells were analyzed and plotted. Data represent mean ± S.E.M. of three independent experiments. *p<0.05.