Table 3.
Accuracy of Prepared Antineoplastic and Adjuvant Medications
| Agent | Baseline Period |
Intervention Period |
P |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Total Bags No. | Failed Preparation |
Percent Dose Variation |
Total Bags No. | Failed Preparation |
Percent Dose Variation |
|||||||
| No. | % | Median | Range | No. | % | Median | Range | Failed Preparation | Dose Variation | |||
| Antineoplastics | ||||||||||||
| Busulfan | 5 | 1 | 20 | 2.9 | 7 to −1.5 | 0 | — | — | — | — | NA | NA |
| Cisplatin | 3 | 0 | 0 | 1.8 | 2.3 to −1.3 | 3 | 0 | 0 | 2.2 | 3.6 to −2.0 | 1 | |
| Cyclophosphamide | 48 | 1 | 2.1 | 1.7 | 5.7 to +1.8 | 0 | — | — | — | — | NA | NA |
| Cytarabine | 50 | 9 | 18 | 2.2 | −17.6 to +28.8 | 26 | 1 | 3.8 | 2.0 | −5.8 to +4.1 | .15 | .16 |
| Etoposide | 21 | 3 | 14.3 | 2.7 | −12.0 to +1.1 | 39 | 0 | 0 | 3.8 | −1.3 to +5.0 | .04 | .16 |
| Fludarabine | 22 | 7 | 31.8 | 3.8 | −51.3 to +1.5 | 12 | 0 | 0 | 3.1 | −5.0 to +0.6 | .04 | .26 |
| Methotrexate | 7 | 1 | 14.3 | 2.6 | −8.0 to +2.8 | 0 | — | — | — | — | NA | NA |
| Mitoxantrone | 7 | 1 | 14.3 | 2.7 | −7.0 to +0.2 | 0 | — | — | — | — | NA | NA |
| Total | 163 | 23 | 14.1 | 2.1 | 80 | 1 | 1.3 | 2.9 | < .001 | .13 | ||
| Adjuvants | ||||||||||||
| Leucovorin | 0 | — | — | — | — | 4 | 0 | 0 | 1.8 | −2.6 to −1.1 | NA | NA |
| Mesna | 21 | 0 | 0 | 2.4 | −4.3 to +4.3 | 26 | 0 | 0 | 1.3 | −4.9 to +1.6 | 1 | .05 |
| Total | 21 | 0 | 0 | 2.4 | 30 | 0 | 0 | 1.4 | 1.4 | 1 | .05 | |
| All preparations | 184 | 23 | 12.5 | 2.1 | 110 | 1 | 0.9 | 2.5 | < .001 | .91 | ||
Abbreviation: NA, not applicable.