Figure 1.

Reliability of brain imaging and behavioral assessment of spinal-lesioned and sham-operated animals. a, The right hindpaw representation in S1HL seed network is shown for each group (top row, sham; bottom row, SCI) before surgery (baseline) and 3, 7, and 14 d after surgery. Images were thresholded at a T-value of 3 to highlight the extent of the network, and they were masked by the combined baseline scans for both groups. b, Hindpaw (dorsal surface) mechanical withdrawal thresholds decrease over time and hypersensitivity develops bilaterally after SCI. All values are means ± SE; *p < 0.001, statistically significant difference. Brain images are shown in neurological convention: left side of the image is left side of the brain.