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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Clin Ther. 2012 Nov;34(11):S25–S35. doi: 10.1016/j.clinthera.2012.09.012

Fig. 4.

Fig. 4

(A) The effect of low-frequency ultrasound pulse intensity duration on in vitro release of trypan blue from 200 µl of negative liposomes in hydrogels at 37°C. (B) Effect of microbubble concentration (0, 200, 400 and 800 µl added to the hydrogel) using a 10-s pulse at 6 W/cm2. For both parameters, dye release before (left panel) and after (right panel) each pulse is shown. Data are means ± SD, N = 4. (C) Ultrasound-triggered dye release profile of trypan blue from liposomes suspended with microbubbles in hydrogels, injected subcutaneously into mice. Data are means ± SD, N = 8; * p<0.001. Adapted with permission from ref. 44. Copyright 2010 Elsevier, Inc.