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Zaprinast and cromolyn disodium probably share a common binding site on human GPR35. BRET-based GPR35-β-arrestin-2 interaction assays were performed in HEK293T cells as in Fig. 11 by using human FLAG-GPR35-eYFP. Concentration-response curves to zaprinast were performed in the presence of a range of submaximally effective concentrations of cromolyn disodium. The EC50 of zaprinast was unaffected by the copresence of cromolyn disodium.
