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CID-2745687 is a potent antagonist in β-arrestin-2 interaction assays only at human GPR35. A to C, BRET-based GPR35-β-arrestin-2 interaction assays as in Fig. 2 were performed by using human (●), mouse (■), or rat (▴) FLAG-GPR35-eYFP. In each case an EC80 concentration of zaprinast (A), cromolyn disodium (B), or pamoate (only at human GPR35) (C) was added along with varying concentrations of CID-2745687.
