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CID-2745687 and ML-145 block agonist-mediated internalization of human GPR35 in a concentration-dependent fashion. Experiments akin to those of Fig. 7 examined the ability of varying concentrations of ML-145 (A and C) or CID-2745687 (B and D) to prevent internalization of human (A and B) or mouse (C and D) GPR35 promoted by an EC80 concentration of the identified agonist ligands.
