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Comparison of the potency of agonist ligands at human GPR35
The potency of ligands at human GPR35 is compared in BRET-based β-arrestin-2 recruitment and receptor internalization assays. Results are pEC50 mean ± S.E.M.
| Ligand | β-Arrestin-2 Recruitment | Internalization |
|---|---|---|
| Zaprinast | 5.30 ± 0.03 | 6.01 ± 0.07 |
| Cromolyn disodium | 4.78 ± 0.10 | 5.19 ± 0.10 |
| Pamoate | 7.28 ± 0.07* | 6.86 ± 0.11* |
indicates partial agonist compared with zaprinast.
