Table 2.

Odds ratios and 95% confidence intervals for biomarker levels (quintiles) and risk of pancreatic cancer by sex

	All			Men			Women
	Controls	Cases	OR 95% CI	Controls	Cases	OR 95% CI	Controls	Cases	OR 95% CI
Total homocysteine (μmol/L)
<=7.57	92	99	1.0	29	31	1.0	63	68	1.0
7.57–8.78	92	77	0.7(0.5–1.1)	35	37	1.0(0.5–2.1)	57	40	0.5(0.3–0.9)
8.78–10.19	92	95	1.3(0.8–2.1)	50	49	1.2(0.6–2.6)	42	46	1.3(0.7–2.7)
10.19–12.33	93	105	0.9(0.6–1.5)	59	56	0.9(0.4–1.8)	34	49	1.0(0.5–2.1)
>12.33	92	85	0.7(0.7–1.5)	48	48	1.0(0.4–2.1)	44	37	0.4(0.2–1.0)
Every quintile			1.0(0.9–1.1)			1.0(0.8–1.2)			0.9(0.8–1.1)
P for heterogeneity				0.8
Methionine (μmol/L)
<=20.67	92	109	1.0	38	36	1.0	54	73	1.0
20.67–23.03	92	62	0.6(0.3–0.9)	34	25	1.0(0.5–2.3)	58	37	0.4(0.2–0.7)
23.03–26.26	92	92	0.9(0.5–1.4)	39	40	1.7(0.8–3.6)	53	52	0.5(0.3–1.0)
26.26–30.24	93	98	0.9(0.6–1.5)	54	53	1.6(0.8–3.1)	39	45	0.6(0.3–1.3)
>30.24	92	100	1.0(0.7–1.4)	56	67	1.9(0.9–3.9)	36	33	0.5(0.3–1.1)
Every quintile			1.0(0.9–1.2)			1.2(1.0–1.4)			0.9(0.8–1.1)
P for heterogeneity				<0.01
Folate (nmol/L)
<=9.02	92	123	1.0	48	63	1.0	44	60	1.0
9.02–11.63	92	79	0.6(0.3–0.9)	46	41	0.6(0.3–1.1)	46	38	0.6(0.3–1.3)
11.63–14.81	93	88	0.6(0.4–1.0)	46	43	0.6(0.3–1.2)	47	45	0.6(0.2–1.4)
14.81–20.17	92	75	0.5(0.3–0.8)	46	36	0.5(0.2–0.9)	46	39	0.5(0.2–1.1)
>20.17	92	97	0.8(0.5–1.4)	35	39	0.9(0.4–1.9)	57	58	0.8(0.4–1.8)
Every quintile			1.0(0.9–1.1)			0.9(0.8–1.1)			1.0(0.8–1.2)
P for heterogeneity				1.0
Folate (nmol/L), clinically relevant cut-points
<=5	25	30	1.6(0.7–3.5)	9	61	1.6(0.5–5.2)	16	18	1.5(0.5–4.4)
5–10	106	125	1.4(0.9–2.1)	12	70	1.5(0.9–2.7)	45	55	1.3(0.7–2.4)
10–15	150	139	1.0	71	66	1.0	79	73	1.0
15–20	87	71	0.8(0.5–1.2)	44	35	0.8(0.5–1.5)	43	36	0.8(0.4–1.5)
>20	93	97	1.3(0.9–2.0)	36	39	1.5(0.8–2.9)	57	58	1.4(0.8–2.4)
P for heterogeneity				1.0
Cobalamin (pmol/L)
<=267.31	92	102	1.0	46	57	1.0	46	45	1.0
267.31–330.01	92	86	0.9(0.6–1.4)	51	44	0.6(0.3–1.2)	41	42	1.4(0.7–2.8)
330.01–391.71	93	90	0.9(0.5–1.3)	46	43	0.6(0.3–1.2)	47	47	1.0(0.5–2.0)
391.71–493.61	92	98	1.0(0.7–1.7)	41	41	0.7(0.3–1.4)	51	57	1.5(0.8–3.0)
>493.61	92	86	0.9(0.6–1.5)	37	37	0.6(0.3–1.3)	55	49	1.4(0.7–2.7)
Every quintile			1.0(0.9–1.1)			0.9(0.8–1.1)			1.1(0.9–1.3)
P for heterogeneity				0.3
Pyridoxal phosphate (nmol/L)
<=23.75	91	131	1.0	36	47	1.00	55	84	1.00
23.75–31.59	92	89	0.7(0.4–1.0)	48	46	0.7(0.4–1.3)	44	43	0.6(0.3–1.1)
31.59–39.29	92	67	0.5(0.3–0.8)	46	36	0.7(0.3–1.3)	46	31	0.4(0.2–0.9)
39.29–54.82	92	94	0.7(0.5–1.2)	49	49	0.9(0.5–2.0)	43	45	0.6(0.3–1.2)
>54.82	92	77	0.7(0.4–1.1)	40	43	1.1(0.6–2.3)	52	34	0.4(0.2–0.8)
Every quintile			0.9(0.8–1.0)			1.1(0.9–1.2)			0.8(0.7–1.0)
P for heterogeneity				0.6
Riboflavin (nmol/L)
<=10.24	91	106	1.0	52	58	1.0	39	48	1.0
10.24–14.02	92	88	0.9(0.6–1.4)	47	42	0.8(0.5–1.5)	45	46	1.0(0.5–1.9)
14.02–18.33	92	77	0.8(0.5–1.3)	45	35	0.7(0.4–1.5)	47	42	0.9(0.5–1.9)
18.33–29.22	92	105	1.0(0.7–1.7)	40	44	1.1(0.6–2.2)	52	61	1.0(0.5–2.0)
>29.22	92	82	0.9(0.5–1.4)	35	42	1.3(0.6–2.7)	57	40	0.7(0.4–1.5)
Every quintile			1.0(0.9–1.1)			1.1(0.9–1.3)			0.9(0.8–1.1)
P for heterogeneity				1.0
Flavin mononucleotide (nmol/L)
<=4.65	88	94	1.0	48	56	1.0	40	38	1.0
4.65–6.12	89	92	0.9(0.6–1.4)	36	38	0.8(0.4–1.6)	53	54	1.0(0.5–2.0)
6.12–8.07	88	99	1.1(0.6–1.7)	42	53	1.1(0.6–2.3)	46	46	1.1(0.5–2.1)
8.07–11.55	89	81	0.8(0.5–1.3)	52	35	0.5(0.2–1.0)	37	46	1.3(0.6–2.9)
>11.55	88	75	0.7(0.4–1.3)	36	34	0.7(0.3–1.6)	52	41	0.8(0.4–1.8)
Every quintile			0.9(0.8–1.1)			0.9(0.7–1.1)			1.0(0.8–1.2)
P for heterogeneity				0.8

The OR were estimated from conditional logistic regression based on matching factors and further adjustments for education, smoking status, cotinine concentration in plasma, baseline alcohol drinking, BMI and self-reported diabetes status at baseline.