Table 2.
All | Men | Women | |||||||
---|---|---|---|---|---|---|---|---|---|
Controls | Cases | OR 95% CI | Controls | Cases | OR 95% CI | Controls | Cases | OR 95% CI | |
Total homocysteine (μmol/L) | |||||||||
<=7.57 | 92 | 99 | 1.0 | 29 | 31 | 1.0 | 63 | 68 | 1.0 |
7.57–8.78 | 92 | 77 | 0.7(0.5–1.1) | 35 | 37 | 1.0(0.5–2.1) | 57 | 40 | 0.5(0.3–0.9) |
8.78–10.19 | 92 | 95 | 1.3(0.8–2.1) | 50 | 49 | 1.2(0.6–2.6) | 42 | 46 | 1.3(0.7–2.7) |
10.19–12.33 | 93 | 105 | 0.9(0.6–1.5) | 59 | 56 | 0.9(0.4–1.8) | 34 | 49 | 1.0(0.5–2.1) |
>12.33 | 92 | 85 | 0.7(0.7–1.5) | 48 | 48 | 1.0(0.4–2.1) | 44 | 37 | 0.4(0.2–1.0) |
Every quintile | 1.0(0.9–1.1) | 1.0(0.8–1.2) | 0.9(0.8–1.1) | ||||||
P for heterogeneity | 0.8 | ||||||||
Methionine (μmol/L) | |||||||||
<=20.67 | 92 | 109 | 1.0 | 38 | 36 | 1.0 | 54 | 73 | 1.0 |
20.67–23.03 | 92 | 62 | 0.6(0.3–0.9) | 34 | 25 | 1.0(0.5–2.3) | 58 | 37 | 0.4(0.2–0.7) |
23.03–26.26 | 92 | 92 | 0.9(0.5–1.4) | 39 | 40 | 1.7(0.8–3.6) | 53 | 52 | 0.5(0.3–1.0) |
26.26–30.24 | 93 | 98 | 0.9(0.6–1.5) | 54 | 53 | 1.6(0.8–3.1) | 39 | 45 | 0.6(0.3–1.3) |
>30.24 | 92 | 100 | 1.0(0.7–1.4) | 56 | 67 | 1.9(0.9–3.9) | 36 | 33 | 0.5(0.3–1.1) |
Every quintile | 1.0(0.9–1.2) | 1.2(1.0–1.4) | 0.9(0.8–1.1) | ||||||
P for heterogeneity | <0.01 | ||||||||
Folate (nmol/L) | |||||||||
<=9.02 | 92 | 123 | 1.0 | 48 | 63 | 1.0 | 44 | 60 | 1.0 |
9.02–11.63 | 92 | 79 | 0.6(0.3–0.9) | 46 | 41 | 0.6(0.3–1.1) | 46 | 38 | 0.6(0.3–1.3) |
11.63–14.81 | 93 | 88 | 0.6(0.4–1.0) | 46 | 43 | 0.6(0.3–1.2) | 47 | 45 | 0.6(0.2–1.4) |
14.81–20.17 | 92 | 75 | 0.5(0.3–0.8) | 46 | 36 | 0.5(0.2–0.9) | 46 | 39 | 0.5(0.2–1.1) |
>20.17 | 92 | 97 | 0.8(0.5–1.4) | 35 | 39 | 0.9(0.4–1.9) | 57 | 58 | 0.8(0.4–1.8) |
Every quintile | 1.0(0.9–1.1) | 0.9(0.8–1.1) | 1.0(0.8–1.2) | ||||||
P for heterogeneity | 1.0 | ||||||||
Folate (nmol/L), clinically relevant cut-points | |||||||||
<=5 | 25 | 30 | 1.6(0.7–3.5) | 9 | 61 | 1.6(0.5–5.2) | 16 | 18 | 1.5(0.5–4.4) |
5–10 | 106 | 125 | 1.4(0.9–2.1) | 12 | 70 | 1.5(0.9–2.7) | 45 | 55 | 1.3(0.7–2.4) |
10–15 | 150 | 139 | 1.0 | 71 | 66 | 1.0 | 79 | 73 | 1.0 |
15–20 | 87 | 71 | 0.8(0.5–1.2) | 44 | 35 | 0.8(0.5–1.5) | 43 | 36 | 0.8(0.4–1.5) |
>20 | 93 | 97 | 1.3(0.9–2.0) | 36 | 39 | 1.5(0.8–2.9) | 57 | 58 | 1.4(0.8–2.4) |
P for heterogeneity | 1.0 | ||||||||
Cobalamin (pmol/L) | |||||||||
<=267.31 | 92 | 102 | 1.0 | 46 | 57 | 1.0 | 46 | 45 | 1.0 |
267.31–330.01 | 92 | 86 | 0.9(0.6–1.4) | 51 | 44 | 0.6(0.3–1.2) | 41 | 42 | 1.4(0.7–2.8) |
330.01–391.71 | 93 | 90 | 0.9(0.5–1.3) | 46 | 43 | 0.6(0.3–1.2) | 47 | 47 | 1.0(0.5–2.0) |
391.71–493.61 | 92 | 98 | 1.0(0.7–1.7) | 41 | 41 | 0.7(0.3–1.4) | 51 | 57 | 1.5(0.8–3.0) |
>493.61 | 92 | 86 | 0.9(0.6–1.5) | 37 | 37 | 0.6(0.3–1.3) | 55 | 49 | 1.4(0.7–2.7) |
Every quintile | 1.0(0.9–1.1) | 0.9(0.8–1.1) | 1.1(0.9–1.3) | ||||||
P for heterogeneity | 0.3 | ||||||||
Pyridoxal phosphate (nmol/L) | |||||||||
<=23.75 | 91 | 131 | 1.0 | 36 | 47 | 1.00 | 55 | 84 | 1.00 |
23.75–31.59 | 92 | 89 | 0.7(0.4–1.0) | 48 | 46 | 0.7(0.4–1.3) | 44 | 43 | 0.6(0.3–1.1) |
31.59–39.29 | 92 | 67 | 0.5(0.3–0.8) | 46 | 36 | 0.7(0.3–1.3) | 46 | 31 | 0.4(0.2–0.9) |
39.29–54.82 | 92 | 94 | 0.7(0.5–1.2) | 49 | 49 | 0.9(0.5–2.0) | 43 | 45 | 0.6(0.3–1.2) |
>54.82 | 92 | 77 | 0.7(0.4–1.1) | 40 | 43 | 1.1(0.6–2.3) | 52 | 34 | 0.4(0.2–0.8) |
Every quintile | 0.9(0.8–1.0) | 1.1(0.9–1.2) | 0.8(0.7–1.0) | ||||||
P for heterogeneity | 0.6 | ||||||||
Riboflavin (nmol/L) | |||||||||
<=10.24 | 91 | 106 | 1.0 | 52 | 58 | 1.0 | 39 | 48 | 1.0 |
10.24–14.02 | 92 | 88 | 0.9(0.6–1.4) | 47 | 42 | 0.8(0.5–1.5) | 45 | 46 | 1.0(0.5–1.9) |
14.02–18.33 | 92 | 77 | 0.8(0.5–1.3) | 45 | 35 | 0.7(0.4–1.5) | 47 | 42 | 0.9(0.5–1.9) |
18.33–29.22 | 92 | 105 | 1.0(0.7–1.7) | 40 | 44 | 1.1(0.6–2.2) | 52 | 61 | 1.0(0.5–2.0) |
>29.22 | 92 | 82 | 0.9(0.5–1.4) | 35 | 42 | 1.3(0.6–2.7) | 57 | 40 | 0.7(0.4–1.5) |
Every quintile | 1.0(0.9–1.1) | 1.1(0.9–1.3) | 0.9(0.8–1.1) | ||||||
P for heterogeneity | 1.0 | ||||||||
Flavin mononucleotide (nmol/L) | |||||||||
<=4.65 | 88 | 94 | 1.0 | 48 | 56 | 1.0 | 40 | 38 | 1.0 |
4.65–6.12 | 89 | 92 | 0.9(0.6–1.4) | 36 | 38 | 0.8(0.4–1.6) | 53 | 54 | 1.0(0.5–2.0) |
6.12–8.07 | 88 | 99 | 1.1(0.6–1.7) | 42 | 53 | 1.1(0.6–2.3) | 46 | 46 | 1.1(0.5–2.1) |
8.07–11.55 | 89 | 81 | 0.8(0.5–1.3) | 52 | 35 | 0.5(0.2–1.0) | 37 | 46 | 1.3(0.6–2.9) |
>11.55 | 88 | 75 | 0.7(0.4–1.3) | 36 | 34 | 0.7(0.3–1.6) | 52 | 41 | 0.8(0.4–1.8) |
Every quintile | 0.9(0.8–1.1) | 0.9(0.7–1.1) | 1.0(0.8–1.2) | ||||||
P for heterogeneity | 0.8 |
The OR were estimated from conditional logistic regression based on matching factors and further adjustments for education, smoking status, cotinine concentration in plasma, baseline alcohol drinking, BMI and self-reported diabetes status at baseline.